In this thesis we use Josephson and noise scanning tunneling microscopy for the study of conventional, unconventional (iron-based) and disordered superconductors. On the one hand, Josephson scanning tunneling microscopy allows us to directly visualize the superfluid density with high spatial resolut…

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

Martijn Junte verdedigde zijn proefschrift op 21 september 2017

Galaxies form and evolve through close interaction with their surroundings. As a result, the heavy elements ('metals') that are synthesized in stars, are found both inside and outside galaxies.

Promotor: Prof.dr. M. Franx, Co-Promotor: Rychard Bouwens

The parabolic Anderson model (PAM), which is the Cauchy problem for the heat equation with random potential. The PAM is a mathematical model that describes how mass (i.e. matter or energy) flows in a medium in the presence of a field of sources and sinks.

Humans share meaning through language. Over time, repeated interactions have shaped languages into forms that match our cognitive preferences, making them structured, expressive, easy to learn, and ultimately, meaningful.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

Het Research Lab for the Study of Heritage Languages of the Netherlands (HERLING) is een platform voor onderzoek naar erfgoedtalen die in Nederland worden gesproken, met een focus op Turks, Bahasa Indonesia, Spaans, Papiamento, Berbers, Arabisch en Duits. HERLING wil een brug slaan tussen wetenschappelijk…

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

In eight chapters, the thesis of Rafaël Vos covers the effect of temperature and pressure on the electrochemical CO2 reduction.

This thesis is about cosmological inflation and its relation to observations.

This thesis concerns the relation bettween the good reduction of Shimura varieties and the associated loop groups.

The idea of citizens and public professionals collaborating to provide public services has widely spread in several countries around the globe. Co-production is often presented as the go-to solution for challenges like a legitimacy crisis of both the government and the market, and financial concerns.…

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

Gold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence.

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…

This thesis consists of three papers that are centered around the common theme of Hausdorff uo-Lebesgue topologies and convergence structures on vector lattices and on vector lattices and vector lattice algebras of order bounded operators.

De focus van dit proefschrift is het leren en de samenwerking van docenten in het voortgezet onderwijs.

Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

The main object of study in this thesis is an Arakelov inequalitywhich bounds the degree of an invertible subsheaf of the direct image ofthe pluricanonical relative sheaf of a semistable family of curves.

Promotor: Prof.dr. J.N. Kok

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Forming at the nodes of the Cosmic Web and growing hierarchically via mass accretion, galaxy clusters are the largest virialized halos in our universe, composed of dark matter (DM; ≥85%), ionized hot plasma in the intracluster medium (ICM; ≥10-15%), and galaxies (≥1-5%).

Most of current public-key cryptography is considered insecure against attacks from sufficiently powerful quantum computers. Post-quantum cryptography studies methods to secure information resistant against such attacks. One proposal is isogeny-based cryptography, which bases its security on computational…

This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

The Sun and all the stars in the night sky reside in the Milky Way galaxy. In the at-rest reference frame of the Galaxy, typical stars travel with velocities of about 100-200 kilometres per second.

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

Onderzoekers aangesloten bij het Leiden Leadership Centre zijn actieve leden van het PUPOL netwerk. PUPOL is een internationaal academisch netwerk voor publiek en politiek leiderschap. Dit netwerk stimuleert de uitwisseling van ideeën en bevordert gezamenlijk onderzoek tussen wetenschappers gericht…

In the past decade many population studies have been performed with the Atacama Large Millimeter/submillimeter Array (ALMA) to understand the bulk properties of protoplanetary disks around young stars. These population studies mostly consisted of low mass stars, with relatively few of the disks around…

In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.

Supply risks are not new. But the aggravation of power conflicts on the international stage coupled with global shifts towards energy transition and digitalization has triggered the next supply risk research era.

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

Teaching the Future: AI-Enhanced Education for Student Engagement and Ethical Learning.

The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…

This thesis contributes to studying primordial cosmology theories and their detectability in future observations.

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

Promotor: Prof.dr. E.J.J. Groenen, Co-Promotor: M. Huber