This dissertation presents a new perspective on the life, work and character of the Dutch physical chemist Jacobus Henricus van ’t Hoff, first recipient of the Nobel Prize in Chemistry, and one of the most important and colourful scientists in Dutch history. The image of Van ’t Hoff that emerges from…

Promotor: A. Achúcarro, Co-Promotor: J.W. van Holten

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

A single self-assembled semiconductor quantum dot in a high-finesse optical microcavity - the subject of this thesis - is an interesting quantum-mechanical system for future quantum applications. For instance, this system allows trapping of an extra electron and thus can serve as a spin quantum memory,…

Artin L-functions associated to continuous representations of the absolute Galois group G_K of a global field K capture a lot of information about G_K as well as arithmetic properties of K.

Promotor: A.P. IJzerman

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

In this thesis integral points on affine del Pezzo surfaces are studied.

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

Multi-objective evolutionary computation aims to find high quality (Pareto optimal) solutions that represent the trade-off between multiple objectives.

How can we bridge the gap between experts and the general public?

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

Promotor: A.P. IJzerman

The complexity of an intelligence problem determines to a great extent the certainty that can be provided by intelligence and security services.

The origin and evolution of galaxies are closely tied to the cyclic feedback processes between stars and the interstellar medium (ISM).

On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.

Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.

In recent decades, climate change has led to more frequent and severe drought events, causing serious consequences such as increased forest mortality and significant crop yield losses. Understanding how drought affects plants, especially economically important herbaceous species, is crucial for predicting…

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Studievoorlichting

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert

Learning from small data sets in machine learning is a crucial challenge, especially when dealing with data imbalances and anomaly detection. This thesis delves into the challenges and methodologies of learning from small datasets in machine learning, with a particular focus on addressing data imbalances…

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Promotor: F.S. de Boer, Co-promotor: M.M. Bonsangue

CML-IA is a database that contains characterisation factors for life cycle impact assessment (LCIA) and is easily read by the CMLCA software program.

The upscaling of Life Cycle Assessment (LCA) data is recognized as one of the main challenges in the ex-ante LCA of emerging technologies. This challenge arises since industrial-scale system specifications for these technologies are unknown and industrial data is lacking.

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

The ultimate goal of cosmologists is to find a cosmological model able to explain the current observational data.

Promotor: M. Franx, Co-Promotor: I.F. Labbé

Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.

Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Promotor: Prof.dr. H. J. A. Röttgering, Co-Promotor: M. Haverkorn

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Tuberculosis is a major global health problem caused by the Mycobacterium tuberculosis complex, claiming more than a million lives annually.

This PhD-thesis analyses the relationship between the parties’ choices in the CPB Netherlands Bureau for Economic Policy Analysis’ assessments of the election manifestos and coalition agreements over the period 1986-2017, and tries to explain this relationship.

Lezing

Join-in courses zijn MA-cursussen over middeleeuwse onderwerpen gegeven binnen vastgestelde MA-programma's van de zes deelnemende universiteiten van de Onderzoekschool. Op aanvraag zijn deze vakken toegankelijk voor studenten van andere (Nederlandse) universiteiten. De cursusbelasting en het aantal…

Moritz Jesse has been awarded a Jean Monnet Chair by the European Commission. In his MIND-EU Project he will focus on a coherent way to teach Migration, Integration, and Non-Discrimination at Leiden Law School at bachelor and master level.