Surface plasmons (SPs) are surface waves at the interface between a dielectric and a good metal, and are formed by the interaction between light and the free electrons at the metal-dielectric interface. They provide strong field confinement for optical fields, opening new possibilities for enhanced…

Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

A key step in the synthesis of oligosaccharides and glycoconjugates is the formation of the glycosidic bond.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

Promotor: J. A. Bouwstra

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

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Van de hand van Hans-Martien ten Napel verscheen onlangs bij Routledge een, samen met prof. Sophie van Bijsterveld (Radboud Universiteit Nijmegen) geredigeerde, bundel getiteld Culture, Secularization, and Democracy. Lessons from Alexis de Tocqueville.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

The global agri-food system plays a critical role in food security and environmental issues.

To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

This thesis attempts to interrogate post-1991-2015 political development in Ethiopia, focusing on the political discourses espoused by the government and opposition, using the discourse analysis method and securitization theory.

Religious Studies at Leiden University allows you to study a broad spectrum of religions and their manifestations.

De onderzoeksgroep War, Peace and Justice onderzoekt de samenhang tussen oorlog, vrede en gerechtigheid. Met een multidisciplinaire aanpak brengen onderzoekers en praktijkdeskundigen nieuwe inzichten in conflict, duurzame vrede en mensenrechten, met bijzondere aandacht voor gender en veiligheid.

Promotores: G.A. Persoon, H.H. de Iongh

Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

De onderzoeksgroep Diplomacy and Global Affairs richt zich op internationale diplomatie, governance en vergelijkend onderzoek, met aandacht voor thema's zoals de EU, de VN, uitbreiding van de EU, de rechtsstaat, en democratische achteruitgang.

Promotor: Prof.dr. D. Bouwmeester, Co-Promotor: M.J.A. de Dood

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Learning from small data sets in machine learning is a crucial challenge, especially when dealing with data imbalances and anomaly detection. This thesis delves into the challenges and methodologies of learning from small datasets in machine learning, with a particular focus on addressing data imbalances…

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Om de juiste klinische beslissingen te nemen of effectieve diagnostische testen en behandelingen te kunnen ontwikkelen, is het belangrijk om de onderliggende mechanismen van een aandoening of een bepaald gedrag te begrijpen.

CONSENT (Consumer sentiment regarding privacy on user generated content services in the digital economy) is a research project funded by the European Union under the 7th Framework Programme. The question central to this research is whether recent changes to consumer and commercial practices developed…

Op 16 juni 2020 verdedigde Andrea Varga haar proefschrift 'Establishing State Responsibility in the Absence of Effective Government'. Het promotieonderzoek is begeleid door promotoren prof. dr. N.J. Schrijver en prof. dr. F. Baetens (University of Oslo).

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Promotor: Prof.dr. J.W.M. Frenken

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Welke rol spelen stress en angst bij de vorming van nocebo hyperalgesie?

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.

Promotor: Prof.dr. H. J. A. Röttgering, Co-Promotor: M. Haverkorn

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.