Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf

This thesis investigates the structural evolution and assembly of galaxies since the first few billions years after the big bang.

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

Gamic Learning in East Asian Studies - Wat kunnen spellen ons vertellen over de manier waarop mensen leren?

A plasma is an ionized gas with very low electrical resistivity. As such, magnetic field lines are 'frozen in' and move with the fluid. Magnetic field lines that are linked, knotted and tangled, cannot be undone by the fluid motions.

In this thesis we use Josephson and noise scanning tunneling microscopy for the study of conventional, unconventional (iron-based) and disordered superconductors. On the one hand, Josephson scanning tunneling microscopy allows us to directly visualize the superfluid density with high spatial resolut…

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

This thesis discusses the discovery potential of Intensity Frontier experiments.

We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.

This thesis is about cosmological inflation and its relation to observations.

In Leiden zijn vele bijzondere en belangrijke ontdekkingen gedaan. Zwerf door de stad en ontdek ter plekke de boeiende verhalen die er achter zitten. Het enige wat je nodig hebt is je smartphone!

Promotors: Prof.dr. J. Zaanen, Prof.dr.ir. H. Hilgenkamp

Werken bij een topfaculteit? Ontdek de vacatures bij Wiskunde en Natuurwetenschappen en solliciteer meteen.

Matthias Flór ontvangt de KHMW Afstudeerprijs Theoretische Natuurkunde voor zijn masterscriptie. Zijn onderzoek naar exotische supergeleiders bij de Universiteit Leiden en TU Delft viel in de smaak bij de jury. De jury koos unaniem voor Flór en merkte op dat 'hij indrukwekkende technische vaardigheden…

Célia Fonseca Guerra heeft samen met haar VU-promovenda Stephanie van der Lubbe quantumchemisch verklaard waarom het guanine-guanine basepaar kortere waterstofbruggen heeft en sterker gebonden is dan het cytosine-cytosine paar. Met haar ontdekking haalde Fonseca Guerra de Front Cover van het blad Chemistry…

Promotor: P.M. Brakefield

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

De effecten van veel behandelingen worden in belangrijke mate bepaald door andere factoren dan het geneesmiddel of de behandeling zelf. Zo kunnen placebo-effecten even groot zijn als het effect van bijvoorbeeld antidepressiva of pijnstillers. Factoren die hieraan bijdragen zijn het vertrouwen in de…

Promotie

Promotie

Today, knowledge is the most crucial element to stimulate organizational competitiveness and economic development.

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

‘Schiedsgerichte in den Aussenverträgen der EU. Neue Entwicklungen unter Einbezug der institutionellen Verhandlungen Schweiz–EU’, Jusletter 28 mei 2018

Promotor: Prof.dr. S.F. Portegies Zwart

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

This dissertation was to develop effective graphene-based nanofluidic devices by developing scalable fabrication methods and elucidating proton transport mechanisms.

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

COI@Leiden organises activities and events throughout the year. These include a monthly seminar series on topics relating to conflict resolution and PhD labs to assist COI students in developing their research skills.

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

Wat is er nodig om een mens te maken? Een uitdijend heelal. Gebouwd uit deeltjes, ruimte en tijd, en hun subtiele mechanismen.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

Promotor: Prof.dr. J.P. Abrahams

Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…

Promotor: J.M. Memelink

Promotor: Prof.dr. M. Ubbink

This thesis tackles the urgent challenge of antimicrobial resistance (AMR) through the design of novel antibacterial agents.