Promotor: S.M. Verduyn Lunel, Co-Promotor: O.W. van Gaans

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…

Promotores: P. Stevenhagen, E. Fouvry (Univeriste Paris Saclay)

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

This thesis deals with properties of Jacobians of genus two curves that cover elliptic curves.

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

Promotor: W.T. de Groot

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

Promotor: R. Cramer

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Promotor: J. Aarts

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Globally and regionally, biodiversity is declining and there are shifts in species’ occurrences and functional traits.

Supervisor: P.J.J. Hooykaas

Plastics have become an integral part of modern society due to their versatility and durability.

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

This thesis investigates catalytic reactions at the atomic scale using scanning tunneling microscopy (STM), with a focus on Fischer–Tropsch synthesis, a key industrial process that converts hydrogen and carbon monoxide into liquid fuels.

This thesis investigates innovative and classical strategies in glycoconjugate vaccine development to address the growing threat of multidrug-resistant bacterial infections.

In this thesis the links between allergy and intestinal health, the gut microbiome (GM), and external factors were studied by exploring the metabolome in longitudinal clinical studies and in vitro models.

This thesis aims to develop model-based approaches to optimize drug dosing in patients with overweight and (morbid) obesity.

Anionic particles play an important role in biological systems where they fulfil many essential functions for cells.

Participants in this course will learn to support student teachers and new colleagues in their professional development as teachers, with particular emphasis on the context of bilingual or international education, as in the ICLON World Teachers Programme (WTP).

De leesvaardigheid van Nederlandse jongeren daalt al jaren. De voornaamste oorzaak voor die afname is dat veel leerlingen moeite hebben met verdiepend lezen. Leer leerlingen om teksten actief te lezen, en om zo bezig te zijn met het construeren van betekenis. Dat schrijven de Leidse onderzoekers Paul…

Het onderzoek van het Brain and Education Lab richt zich op de ontwikkeling van cognitieve processen die betrokken zijn bij leren en academische vaardigheden zoals begrijpend lezen, wiskunde en ruimtelijke vaardigheden. Daarbij richt het onderzoek zich specifiek op één van de meest opwindende fasen…

Als een kind of jongere in familiaire kring gewoon praat, maar niet of nauwelijks spreekt wanneer anderen in de buurt zijn, kan er sprake zijn van selectief mutisme. Dit valt vooral op wanneer kinderen niet spreken met leerkrachten en/of leeftijdsgenoten. In dit boekje krijg je handvatten om erg stille…

Heb je ooit voor een abstract kunstwerk gestaan en gedacht: “Dat had een aap ook kunnen maken!”? Nou, dat heb je mis.

Het team van wetenschappers binnen TRIXY zorgt ervoor dat er belangrijke kennis verzameld wordt over kwetsbaarheden bij deze kinderen, met name op het gebied van de cognitieve, emotionele, en sociale ontwikkeling, in relatie tot risico op gedragsproblemen.

Op vrijdag 13 februari 2026 neem je deel aan de eerste selectieronde. Deze vindt plaats in het Universitair Sportcentrum in Leiden (de tentamenlocatie van Universiteit Leiden). Praktische informatie hierover ontvang je begin februari.

Op 1 juli 2020 verdedigde Niek Strohmaier zijn proefschrift 'Making Sense of Business Failure'. Het promotieonderzoek is begeleid door promotoren prof.dr. J.A.A. Adriaanse en dr. H. Pluut.

Het Brain and Education lab is een onderzoeksgroep van het Instituut Pedagogische Wetenschappen aan de Universiteit Leiden en maakt deel uit van het Leiden Institute for Brain and Cognition (LIBC). Ons onderzoek richt zich op de ontwikkeling van cognitieve processen die betrokken zijn bij leren en academische…

Op vrijdag 13 februari 2026 neem je deel aan de eerste selectieronde. Deze vindt plaats in het Universitair Sportcentrum in Leiden (de tentamenlocatie van Universiteit Leiden). Praktische informatie hierover ontvang je begin februari.