Risk has become one of the defining features of modern society. This course examines various types of safety and security risks, and how these are perceived and dealt with in a wide array of professional and academic fields, ranging from criminology, counter-terrorism and cyber security, to philosophy,…

In this thesis we study the moduli space of genus g curves, and the differential forms that occur naturally on this moduli space.

Optical cavities are useful tools to enhance the interaction between light and matter, which is important to make good quantum emitters. However, it turns out that the cavities themselves (without any quantum emitters) are already interesting objects to study.

In this thesis, we examine various systems through the lens of several numerical methods.

Indo-European is the name of the language family to which English belongs, along with many sub-families such as Germanic languages and Romance languages. In this course, you will delve into the structure and origins of these branches, the oldest languages belonging to the language family, linguistic…

What are the pressing issues of our time, and how can different disciplines come together to address them? Studium Generale and Leiden University College (LUC) present the Global Challenges series: events that bring together researchers from LUC and experts from other disciplines to tackle a shared…

This thesis describes research aimed at discovering inhibitors selective for either of the two endoplasmic reticulum α-glucosidases, ER-I and ER-II, with the overarching goal of discovering new antiviral agents to treat viruses that rely on host N-glycosylation for proliferation.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Dynamical systems describe the evolution of objects in a space over time and may be used to model physical phenomena. Due to this, much research is dedicated to understanding the mathematics of dynamical systems.

Promotor: Prof.dr. M. Schilthuizen

Promotor: A. Achúcarro, Co-Promotor: J.W. van Holten

In het academisch jaar 2023-2024 biedt het interdisciplinaire onderzoeksprogramma Sociale Veerkracht en Veiligheid vier vakken aan voor studenten die beginnen met het derde jaar van hun bachelor. Deze vakken zijn te volgen binnen de ruimte voor keuzevakken. Je kunt de vakken afzonderlijk als keuzevak…

Machine Learning is becoming a more and more substantial technology for industry.

Multi-objective evolutionary computation aims to find high quality (Pareto optimal) solutions that represent the trade-off between multiple objectives.

Promotor: F.J. van Lunteren, E. Jorin

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Op 23 februari 2022 verdedigde Cale Davis het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. C. Stahn en dr. J.C. Powderly.

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

The upscaling of Life Cycle Assessment (LCA) data is recognized as one of the main challenges in the ex-ante LCA of emerging technologies. This challenge arises since industrial-scale system specifications for these technologies are unknown and industrial data is lacking.

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

Electrons in a crystal lattice have properties that may differ from those of a free electron in vacuum.

Op 16 juni 2020 verdedigde Andrea Varga haar proefschrift 'Establishing State Responsibility in the Absence of Effective Government'. Het promotieonderzoek is begeleid door promotoren prof. dr. N.J. Schrijver en prof. dr. F. Baetens (University of Oslo).

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

Mechanical metamaterials are man-made materials which derive their unusual properties from their structure rather than their composition.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

Promotor: B. van de Water

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

Promotor: P. T. de Zeeuw, Co-promotor: N. Neumayer; G. van de Ven

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Kiemproject: Hoe kunnen metaforen bijdragen aan betere maatschappelijke betrokkenheid bij quantumwetenschap en -technologie, en welke factoren beïnvloeden de acceptatie of weerstand tegen metaforen bij zowel experts als leken?

De dodenherdenking op 4 mei zal dit jaar anders zijn, maar niet minder indrukwekkend. Japanoloog Ethan Mark geeft een online lezing over onderbelichte oorlogsgeschiedenissen. Via Open Joodse Huizen zijn er aangrijpende onlineverhalen te beluisteren over Joodse alumni. En vanaf het Academiegebouw zullen…

Na een lange sluiting in de Tweede Wereldoorlog konden studenten in september 1945 eindelijk weer studeren. Dat werd vier dagen gevierd. Met het cortège, herdenkingsdiensten en een feest in de Hortus. Ook koningin Wilhelmina was erbij. Bekijk de bijzondere foto’s van deze memorabele dagen.

Als twaalfjarig meisje raakte Nicky van de Beek geïntrigeerd door de graftomben in het Egyptische Sakkara. Inmiddels promoveert ze erop, net als een andere Leidse Egyptologe decennia eerder. Herta Mohr beet zich tijdens de Tweede Wereldoorlog vast in haar onderzoek. Nu is ze de naamgeefster van het…

Door elke afzonderlijke beslissing, hoe klein die ook is, maken mensen geschiedenis. Dat zei historicus Katja Happe toen zij op 26 november de Cleveringa-oratie uitsprak. Ze vertelde erover aan de hand van individuele reacties op de Jodenvervolging tijdens de Tweede Wereldoorlog.

Bijna 81 jaar na zijn befaamde speech tegen de Duitse bezetter, wordt de Leidse hoogleraar Rudolph Pabus Cleveringa herdacht in zijn Groningse geboortestad Appingedam. Op 12 november wordt daar een standbeeld onthuld en zijn er diverse andere activiteiten.

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

Promotor: Prof.dr. C.U. Keller

Traditional hypothesis testing requires researchers to set a fixed sample size in advance. After collecting data, the test determines whether to reject the null hypothesis.

Promotores: H.W. Lenstra, B. Erez, Co-promotor: L. Taelman

We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.