Learning from small data sets in machine learning is a crucial challenge, especially when dealing with data imbalances and anomaly detection. This thesis delves into the challenges and methodologies of learning from small datasets in machine learning, with a particular focus on addressing data imbalances…

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Om de juiste klinische beslissingen te nemen of effectieve diagnostische testen en behandelingen te kunnen ontwikkelen, is het belangrijk om de onderliggende mechanismen van een aandoening of een bepaald gedrag te begrijpen.

Op 16 juni 2020 verdedigde Andrea Varga haar proefschrift 'Establishing State Responsibility in the Absence of Effective Government'. Het promotieonderzoek is begeleid door promotoren prof. dr. N.J. Schrijver en prof. dr. F. Baetens (University of Oslo).

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Promotor: Prof.dr. J.W.M. Frenken

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Welke rol spelen stress en angst bij de vorming van nocebo hyperalgesie?

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.

Promotor: Prof.dr. H. J. A. Röttgering, Co-Promotor: M. Haverkorn

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Wetlands provide many ecosystem goods and services which include fish production. The sustainability of small-scale fisheries (SSF) has received considerable attention in recent years because fish is one of the major sources of animal protein to a considerable fraction of the global population which…

Het vertrekpunt van dit onderzoek is de bevinding dat het menselijk brein vatbaar is voor allerlei denkfouten en vooringenomenheden (biases), die onze percepties kleuren en onze redenaties beïnvloeden, zonder dat we dit bewust doorhebben. Integendeel, mensen hebben veelal het gevoel dat zij slechts…

De onderzoeksgroep Terrorism and Political Violence van de Universiteit Leiden bestudeert de oorzaken van radicalisering, de tactieken van extremistische groeperingen, en de effectiviteit van anti-terrorismebeleid. We onderzoeken ook de rol van media en de invloed van postkoloniale erfenissen in de…

Het ICLON doet onderzoek naar het basis- en voortgezet onderwijs.

Safety First. How local processes of securitization have affected the position and role of Dutch mayors. Nederlandse burgemeesters super-netwerkers. Nederlandse burgemeesters zien zich anno 2014 geconfronteerd met een grote variëteit aan nieuwe veiligheidsvraagstukken, waaronder radicalisering, loverboys…

Lezing

Studievoorlichting, On Campus Experience

Workshop

Hoe beïnvloedt de vernietiging van universiteiten in Gaza, ook wel 'scholasticide' genoemd, het wetenschappelijk leven en wat zijn de theoretische en juridische onderbouwingen van de term?

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

Promotor: G.A. Persoon, Co-promotor: H.H. de Iongh

De effecten van veel behandelingen worden in belangrijke mate bepaald door andere factoren dan het geneesmiddel of de behandeling zelf. Zo kunnen placebo-effecten even groot zijn als het effect van bijvoorbeeld antidepressiva of pijnstillers. Factoren die hieraan bijdragen zijn het vertrouwen in de…

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

ISGA in Den Haag biedt bachelor- en masteropleidingen, minoren en onderzoek in security studies, cybersecurity, terrorisme, diplomatie en actuele veiligheidsvraagstukken. Focuspunten: bachelor, master, minoren, onderzoek, security studies, cybersecurity, terrorisme, diplomatie, veiligheidsvraagst…

Studievoorlichting, On Campus Experience

Onderwijsonderzoek

Het Leiden University Centre for Linguistics (LUCL) is een van de instituten van de Faculteit Geesteswetenschappen.

In this thesis, single-cell approaches were applied to characterize the impact of aging on the immunological B cell landscape in different models of atherosclerotic cardiovascular disease, with the goal to identify and study new B cell-associated biomarkers and therapeutic targets to halt atherosclerosis…

Studievoorlichting

De onderzoeksgroep Organizational & Entrepreneurial Behavior onderzoekt het gedrag van individuen en groepen die in organisaties werken, organisaties starten, of organisaties leiden, met als doel om organisatorische praktijken te informeren. Door zich te concentreren op het gedrag van (groepen) werknemers,…

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Lezing, SMILE Talks

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