Prof.dr. J. Memelink

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

Promotor: H.V.J. Linnartz

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

De staf van het Instituut voor Wijsbegeerte bestudeert alle aspecten van de filosofie. In ons onderzoek streven wij naar een vruchtbare interactie tussen systematische en historische benaderingen van de filosofie. Wij werken in een context van intensieve nationale en internationale samenwerking.

Gibbs measures, as used in Statistical Mechanics, have a definition that is remarkably similar to the definition ofg-measures, used in dynamical systems.

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

In this thesis, rational points on K3 surfaces are studied. In the first part of Chapter 1 the Brauer group and the the Brauer-Manin obstruction are introduced.

This thesis investigates opinion dynamics on random graphs through the lens of the voter model, a classical interacting particle system used to describe how consensus emerges in networks.

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

A key step in the synthesis of oligosaccharides and glycoconjugates is the formation of the glycosidic bond.

Hoe kunnen we scholen helpen stress en angst in de klas te herkennen en te voorkomen en samen met scholen leerlingen snel de juiste ondersteuning bieden? Op weg naar een structurele samenwerking tussen Leidse scholen en LUBEC Kenniscentrum Angst en Stress bij jeugd.

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CONSENT (Consumer sentiment regarding privacy on user generated content services in the digital economy) is a research project funded by the European Union under the 7th Framework Programme. The question central to this research is whether recent changes to consumer and commercial practices developed…

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

Om de juiste klinische beslissingen te nemen of effectieve diagnostische testen en behandelingen te kunnen ontwikkelen, is het belangrijk om de onderliggende mechanismen van een aandoening of een bepaald gedrag te begrijpen.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Learning from small data sets in machine learning is a crucial challenge, especially when dealing with data imbalances and anomaly detection. This thesis delves into the challenges and methodologies of learning from small datasets in machine learning, with a particular focus on addressing data imbalances…

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

Promotor: Prof.dr. D. Bouwmeester, Co-Promotor: M.J.A. de Dood

Op 16 juni 2020 verdedigde Andrea Varga haar proefschrift 'Establishing State Responsibility in the Absence of Effective Government'. Het promotieonderzoek is begeleid door promotoren prof. dr. N.J. Schrijver en prof. dr. F. Baetens (University of Oslo).

Religious Studies at Leiden University allows you to study a broad spectrum of religions and their manifestations.

To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.

This thesis attempts to interrogate post-1991-2015 political development in Ethiopia, focusing on the political discourses espoused by the government and opposition, using the discourse analysis method and securitization theory.

De onderzoeksgroep War, Peace and Justice onderzoekt de samenhang tussen oorlog, vrede en gerechtigheid. Met een multidisciplinaire aanpak brengen onderzoekers en praktijkdeskundigen nieuwe inzichten in conflict, duurzame vrede en mensenrechten, met bijzondere aandacht voor gender en veiligheid.

Promotores: G.A. Persoon, H.H. de Iongh

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

The global agri-food system plays a critical role in food security and environmental issues.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.