This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Stars and planets form within cold, dense clouds of gas and dust drifting through interstellar space. Although dust makes up only a small fraction of this material, it plays a key role in shaping the chemical evolution of these environments.

Promotor: A. Kros

Binnen de afdeling Civiel recht concentreert het onderzoek zich op de coherentie van het privaatrecht.

Op 28 oktober 2021 verdedigde Hein van der Bruggen zijn proefschrift en behaalde daarmee de doctorstitel.

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Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

Promotor: G.P. van Wezel

Van zelfrijdende auto’s tot innovatieve medicijnontwikkeling, kunstmatige intelligentie (AI) gaat ons leven op uiteenlopende manieren fundamenteel veranderen. Onze computerwetenschappers bestuderen de technologie op een diep en fundamenteel niveau. Maar we zoeken ook naar medische toepassingen en antwoorden…

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

Striga hermonthica, commonly known as witchweed, infests major cereal crops in Sub-Saharan Africa causing severe yield losses and threatening the livelihood of millions of resource poor farmers.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

This research delves into a region of space known as the interstellar medium (ISM), which is essentially the area between the stars filled with gas and dust.

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

Ontdek de extra uitdagingen bij de MSc Political Theory: Legitimacy and Justice aan Universiteit Leiden — zoals de Honours Academy, leadershiptrainingen en extra onderzoeks- of verdiepingstrajecten.

Ben jij een nieuwsgierige en enthousiaste student en wil je meer naast je studie doen? Dan is het honoursonderwijs misschien wel iets voor jou.

Haal zoveel mogelijk uit je studie aan de Univeriteit Leiden door deel te nemen aan onze extracurriculaire activiteiten.

Bekijk de extra uitdagingen binnen de MSc International Organisation (Leiden). Ontdek het Honours-programma, Leiden Leadership Programme en academische challenges.

Haal zoveel mogelijk uit je studie aan de Univeriteit Leiden door deel te nemen aan onze extracurriculaire activiteiten.

Haal zoveel mogelijk uit je studie aan de Univeriteit Leiden door deel te nemen aan onze extracurriculaire activiteiten.

Versterk je MSc The Politics of Artificial Intelligence met de Honours Academy van Universiteit Leiden: kies tussen het éénjarige Leiden Leadership Programme (15 EC) of interdisciplinaire Master Honours Challenges (3–5 EC) om je vaardigheden en impact te vergroten.

Ontdek de extra uitdaging binnen de MSc Democracy and Representation aan Universiteit Leiden: het Leiden Leadership Programme en Master Honours Classes & Challenges met extra EC’s.

Ben jij een nieuwsgierige en enthousiaste student en wil je meer naast je studie doen? Dan is het honoursonderwijs misschien wel iets voor jou.

Where does the urge to collect come from? What are the explicit or underlying reasons for gathering large amount of objects?

De afdeling Environmental Biology (CML-EB) houdt zich bezig met vraagstukken rondom biodiversiteit en natuurlijke hulpbronnen op het platteland in westerse en niet-westerse gebieden.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Songbirds as vocal learners learn their songs and song preference from social tutors⁠. Tutor choice for both song and preference learning are important to characterize for understanding individual learning performance and cultural transmission of song⁠.

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Bij de uitbreiding van het Gorlaeus Gebouw zijn veel interne en externe partijen betrokken.

Mycoheterotrophy is a particular mode of life in which plants obtain carbohydrates from their associated fungal partners, instead of by using photosynthesis.

The demand for neodymium-iron-boron (NdFeB) magnets is rapidly growing, while the neodymium supply chain is under pressure. Recycling can alleviate these issues. This thesis investigates the potential for deploying novel magnet recycling technologies and their environmental consequences.

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

Dit boek, samengesteld door voormalig BVD-historicus Dick Engelen en historicus Constant Hijzen, geeft een overzicht van lokaties in Nederland die in de twintigste eeuw iets te maken hebben gehad met spionage en geheime diensten uit binnen- en buitenland.

Low-mass main-sequence stars like our Sun are continuous sources of outflowing hot magnetised plasma. In the case of the Sun, this is known as the solar wind, whereas for other stars they are called stellar winds.

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

Promotores: G. Persoon, R. Schefold

Dr. Helen Pluut heeft een artikel gepubliceerd in het gerenommeerde tijdschrift Organizational Behavior and Human Decision Processes (OBHDP). Dit in samenwerking met Remus Ilies (National University of Singapore), Petru Curşeu (Open Universiteit en Babeş-Bolyai University) en Yukun Liu (University of…

The department of Industrial Ecology is dealing with research into the development of tools for decision making on sustainable production and consumption.

Promotores: Prof.dr. A.G.G.M. Tielens, Prof.dr. L. Kaper (UvA)

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)