In a typical glycosylation reaction, a donor is activated to form a (variety of) electrophilic species which can react with a nucleophilic acceptor, following a reaction mechanism having both SN1 and SN2 character.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

Als eersten ter wereld hebben studenten van de Leidse master Computer Science les gehad in het programmeren van een quantumcomputer. ‘Hiermee zijn eindelijk de complexe levensechte problemen van de maatschappij op te lossen.’

Onderzoek naar quantumcomputers en islamitische goede doelen: twee Leidse wetenschappers krijgen een Consolidator Grant van de European Research Council.

Transcutaneous vagus nerve stimulation (tVNS) was tested in chronic worriers. tVNS may reduce spontaneously occurring negative thought intrusions. After a worry induction, there was no longer an effect of tVNS. tVNS did not affect physiological responding to worrying.

The interest of this thesis lies in spin transport in normal metals and superconducting half-metallic junctions.

Met zijn ijskoude nanokrachtsensor zoekt Tjerk Oosterkamp naar de grens tussen de quantumwereld en de wereld van alledag. De Leids natuurkundige heeft een NWO-subsidie van 600.000 euro binnengehaald.

Voor de Internationale Dag van Vrouwen en Meisjes in de Wetenschap vertellen vrouwelijke studenten en onderzoekers uit de natuurkunde over wat hen inspireert in hun werk. Van kwantum tot kosmologie en biofysica, hun nieuwsgierigheid naar hoe de natuur werkt is wat deze vrouwen verbindt. Wat willen deze…

Is teleportatie het vervoermiddel van de toekomst? Welke invloed had de 16e-eeuwse geleerde Scaliger op het besef van tijd? Ontdek het in de Nacht van Ontdekkingen op zaterdag 15 september in Leiden! Wetenschappers geven flitscolleges en buigen zich samen met het publiek, kunstenaars en muzikanten over…

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

This course explores international arbitration as one of the most common methods of international dispute settlement. You will gain an in-depth understanding of international arbitration through the analysis of its role as a mechanism of dispute settlement, its institutions, the fields of law it is…

Promotor: G.J.B. van Ommen

This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Welke rol spelen de leiderschapsstijl en de visie op leraren en leerlingen van schoolleiders in het bevorderen van een positief werkklimaat voor leraren en een positief leerklimaat voor leerlingen op scholen met een hoge schoolweging?

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Op welke manieren hebben ontwikkeling van digitale technologieën invloed op de samenleving en de regulerings- en juridische kaders binnen de samenleving?

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Algemene contactinformatie

Onderzoek aan het Leids Instituut voor Onderzoek in de Natuurkunde (LION) is fundamenteel en nieuwsgierigheids-gedreven. Al onze wetenschappers delen de wens om de kennis van de wereld om ons heen te vermeerderen, in een open, nieuwsgierige sfeer, waarin innovatieve ideeën ontstaan die toepassingen…

Op deze pagina vind je de opnames van de Tuesday Talks sinds april 2025. Ook de opnames van de voorloper van de Tuesday Talks, This Week’s Discoveries, zijn hier te vinden

Leiden Institute of Advanced Computer Science (LIACS)

Is het mogelijk om subtiele trillingen te meten die worden veroorzaakt door donkere materie die door de aarde beweegt? Een team van Nederlandse en Amerikaanse natuurkundigen heeft een nieuwe manier gevonden om mogelijk voor het eerst donkere materie te meten. Ze lieten een microscopisch kleine magneet…

M.T.M. Koper, Co-promotor: D.G.H. Hetterscheid

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

With the rise of multi-drug resistant bacterial pathogens, the possibility of a post-antibiotic world is quickly becoming reality.

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Promotores: C.A.M.J.J. van den Hondel, V. Meyer, Co-promotor: A.F.J. Ram

Promotor: J.W.M. Frenken Co-Promotor: R. Felici

Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf