De programmagroep Neuropedagogiek en ontwikkelingsstoornissen heeft expertise in de ontwikkeling van kinderen en adolescenten, met de nadruk op ontwikkelingsstoornissen.

Is het brein van de rechter in staat om bewijs (DNA, camerabeelden) zo te interpreteren dat de waarheid wordt gevonden? Wat betekenen afwijkingen in het brein van de verdachte voor diens toerekeningsvatbaarheid? Kunnen we het brein van veroordeelden zo beïnvloeden dat ze niet zullen recidiveren? Deze…

Het onderzoek van de sectie Sociale, Economische en Organisatiepsychologie is gericht op het ontwikkelen van modellen om beïnvloeding in sociale systemen te beschrijven en te verklaren. Dit wordt onderzocht binnen het domein Sociale en Organisatiepsychologie, en ook binnen de Economische en Consumen…

Sinds april heeft de Faculteit der Sociale Wetenschappen er een nieuwe locatie bij voor haar onderzoek. Het Levelgebouw (direct naast Leiden Centraal) ontvangt proefpersonen in 3 gloednieuwe laboratoria. Psychologen Carsten de Dreu en Mariska Kret vertellen enthousiast over de nieuwe mogelijkheden voor…

Presents a novel philosophical account of psychedelic experiences, arguing that they can be induced by means other than psychedelics — such as meditation and yoga.

Een belangrijke uitdaging in de neurowetenschappen is het begrijpen hoe neuronen in honderden onderling verbonden hersengebieden sensorische input integreren met eerdere verwachtingen om bewegingen te initiëren en beslissingen te nemen.

Studies naar perceptuele besluitvorming presenteren dezelfde stimulus doorgaans herhaaldelijk tijdens een experimentele sessie, maar negeren de volgorde van deze observaties, waarbij wordt uitgegaan van een onrealistische stabiliteit van beslissingsstrategieën tijdens proeven. Maar zelfs ‘stabiel’,…

Elke dag nemen we vele beslissingen; van wat we eten tot hoe we de wereld om ons heen interpreteren. Over het algemeen gingen onderzoekers ervan uit dat een belangrijk onderdeel van ons besluitvormingsproces, namelijk het beslissingscriterium, stabiel blijft. Er zijn echter steeds meer aanwijzingen…

Voor wie geïnteresseerd is in de relatie tussen neuro-cognitieve en biologische factoren enerzijds en leren, gedrag en emoties anderzijds.

Nauwkeurig emoties van anderen herkennen is een essentiële sociale vaardigheid, die relevant is voor het omgaan met de sociale wereld vanaf de kindertijd. Het vermogen van kinderen om dit te doen is een mijlpaal in hun sociaal-emotionele ontwikkeling en wordt geassocieerd met een aantal belangrijke…

Mensen met een licht verstandelijke beperking (LVB) bevinden zich dikwijls in een soort niemandsland. Door de diversiteit van hun problemen doen deze mensen een beroep op uiteenlopende hulpverleningsinstanties van waaruit ze weer worden doorverwezen. Hierdoor krijgen ze vaak niet de ondersteuning die…

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

Promotores: J. Zaanen, A. Parnachev

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids.

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

Promotor: R. Cramer

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Promotor: J. Aarts

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

Promotor: W.T. de Groot

Supervisor: P.J.J. Hooykaas

Promotores: P. Stevenhagen, E. Fouvry (Univeriste Paris Saclay)

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Globally and regionally, biodiversity is declining and there are shifts in species’ occurrences and functional traits.

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

Promotor: M.K. Richardson, Co-Promotor: F. Witte

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu