As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Promotor: Prof.dr. H.S. Overkleeft

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Hydrogen peroxide (H2O2) is an important bulk chemical that is used in various industrial processes. More than 95% of the H2O2 used in industry is made via the anthraquinone process during which a large amount of energy is going to waste.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Before the large scale use of renewable energy sources can be implemented in our society, the storage of electrical energy needs to be tackled. Storage the energy as hydrogen via the reduction of protons is a good option.

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

Dit proefschrift gaat over theoretische oppervlakte chemie binnen het veld van de heterogene katalyse.

In 2021 hebben veel van onze medewerkers en studenten mooie prijzen gewonnen en belangrijke onderzoekssubsidies binnengehaald. Traditioneel blikken we aan het einde van het jaar en bij de start van het nieuwe jaar terug op deze successen.

De Universiteit Leiden zet zich ervoor in dat haar laboratoria een accreditatie krijgen van het Laboratory Efficiency Assessment Framework (LEAF)

Onderzoekers vanuit verschillende vakgebieden werken samen om oplossingen te bedenken voor maatschappelijke problemen.

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

Binnen de Life in Custody Study wordt grootschalig onderzoek gedaan naar het leefklimaat in Nederlandse penitentiaire inrichtingen (PI’s).

Het consortium Advanced Nano-electrochemistry Institute Of the Netherlands (ANION) krijgt een Zwaartekracht-subsidie van 23,6 miljoen euro voor onderzoek naar elektrochemische processen die van belang zijn voor de energietransitie. Daarnaast zijn er nog vier gehonoreerde consortia met een Leidse dee…

Bij kanker groeien lichaamscellen ongecontroleerd. Het gedetailleerd in kaart brengen van hoe dit precies gebeurt maakt het mogelijk om efficiënte therapieën te ontwikkelen. Onderzoekers van het Leids Universitair Medisch Centrum (LUMC) en de Universiteit Leiden werken samen aan het vermeerderen van…

Per 1 augustus is Lars Jeuken gestart als hoogleraar Biophysical Chemistry bij het Leids Instituut voor Chemisch Onderzoek (LIC). Hij doet onderzoek op het snijvlak van biologie en scheikunde, maar er komt ook fysica en nanotechnologie bij kijken. Jeuken: ‘Door nanodeeltjes te koppelen aan eiwitten…

Mario van der Stelt is met ingang van 1 november 2017 benoemd tot hoogleraar Moleculaire Fysiologie aan het Leids Instituut voor Chemisch Onderzoek van de Universiteit Leiden.