A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Promotor: Prof.dr. M. Schilthuizen

Promotor: A. Achúcarro, Co-Promotor: J.W. van Holten

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

In recent decades, climate change has led to more frequent and severe drought events, causing serious consequences such as increased forest mortality and significant crop yield losses. Understanding how drought affects plants, especially economically important herbaceous species, is crucial for predicting…

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert

Op 11 juni 2020 verdedigde Sabine Witting haar proefschrift 'Child Sexual Abuse in the Digital Era: Rethinking Legal Frameworks and Transnational Law Enforcement Collaboration'. Het promotieonderzoek is begeleid door promotoren prof.mr. J.J. Sloth-Nielsen en prof.dr.mr. S. van der Hof.

Op 12 januari 2022 verdedigde Mirjam Franke het proefschrift 'Over de grens van de onrechtmatige daad'. Het promotieonderzoek is begeleid door prof.mr. A.G. Castermans en prof.mr. J.H. Crijns.

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

Online cursus The Importance and Power of Music in our Society

An important part of the SCS specialisation is the internship period. Students will get the opportunity to get to know the field and to apply what they have learned during the courses.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

CONSENT (Consumer sentiment regarding privacy on user generated content services in the digital economy) is a research project funded by the European Union under the 7th Framework Programme. The question central to this research is whether recent changes to consumer and commercial practices developed…

Electrons in a crystal lattice have properties that may differ from those of a free electron in vacuum.

Promotor: M. Franx, Co-Promotor: I.F. Labbé

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

Promotores: J. Kok, M. Chaudron (Chalmers University)

Before the large scale use of renewable energy sources can be implemented in our society, the storage of electrical energy needs to be tackled. Storage the energy as hydrogen via the reduction of protons is a good option.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Promotor: P. T. de Zeeuw, Co-promotor: N. Neumayer; G. van de Ven

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

The zoo of detected exoplanets reveals both the uniqueness of our own Solar System and the complexity of planetary system formation, sparking fundamental questions about how planetary systems form and evolve.

The dissertation offers new tools and insights to computation and modelling of topological phases, with an emphasis on the aperiodic setting.

Studievoorlichting

In Leiden zijn vele bijzondere en belangrijke ontdekkingen gedaan. Zwerf door de stad en ontdek ter plekke de boeiende verhalen die er achter zitten. Het enige wat je nodig hebt is je smartphone!

Studievoorlichting

Workshop

Het Europa Instituut kondigt trots aan dat de prijs voor het beste geschreven pleidooi van de European Law Moot Court (ELCM) competitie gewonnen is door Universiteit Leiden!

Maatschappelijke valorisatie

Workshop

Leiden BuurtKennis is een nieuw burgerwetenschapsproject dat lokale onderzoeksvragen ophaalt uit de Leidse wijken, en deze verbindt met lokale initiatieven, studenten, onderzoekers en de stad om samen kennis en acties te ontwikkelen voor een gezonde en veerkrachtige stad.

Leiden is de ideale, sfeervolle studentenstad, goed bereikbaar midden in de Randstad.

Het Wetenschapsknooppunt Leiden laat kinderen en jongeren kennismaken met wetenschap in samenwerking met scholen.