Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.

Large carnivore population is globally declining as a result of the fragmentation of habitat, large prey depletion and retaliatory killing by pastoralists.

Promotores: E. van Dijk, G.R. de Snoo. Co-promotor: H. Staats

One of the most important correlation functions in physics, especially in cosmology, is the energy density, which describes how much energy is present at each point in spacetime due to matter fields. A key contribution to the energy density of the primordial universe comes from gravitational waves (GWs),…

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

The ability to count is a property not often attributed to materials, despite the abundance of memory in materials. Regardless of how a material stores information, it is often difficult to retrieve exactly ‘what’ a material remembers.

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

Promotor: F. Arbab

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

Constraint multi-objective optimization with a limited budget for function evaluations is challenging. This thesis tackles this problem by proposing new optimization algorithms. These algorithms are applied on holistic ship design problems. This helps naval architects balance objectives like cost, efficiency,…

Promotor: K.J. Batenburg

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

Promotor: Prof.dr. J. Kuiper

Promotor: Prof.dr. M. Ubbink

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.

Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Promotor: E. Gittenberger, Co-promotores: L.P. van Ofwegen; B.W. Hoeksema

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

Promotores: J.N. Kok, H.J. Hoogeboom

This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

In my research, I used a comparative wood anatomical approach to address wood evolution of the (largely) tropical flowering plant families Apocynaceae and Sapotaceae.

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

An interdisciplinary collection of the best international scholarship on Muslim youth.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

My work focuses on a class of astronomical objects called protoplanetary disks.

Promotores: W. Jiskoot, F. Ossendorp

Conventional food supplies procured from rural areas are increasingly vulnerable to disruptions caused by extreme weather, geopolitical instability, and logistical bottlenecks.

Workshop

De Oorlogsgravenstichting publiceert dit jaar ter gelegenheid van het 75-jarig bestaan wekelijks een portret van een oorlogsslachtoffer. Op 24 januari werd de tekening van Irawan Soejono, Leids student en Indonesisch verzetsstrijder, onthuld op de Leidse begraafplaats Groenesteeg, de plek waar Soejono…

Op vijf mei vieren wij de vrijheid, een groot goed dat niet vanzelfsprekend is. Wij vroegen studenten en medewerkers wat vrijheid voor hun betekent.

‘Het Leidse horzelnest moet uitgebrand worden,’ zei de NSB-er Robert van Genechten in november 1942, doelend op de Universiteit Leiden. Vanwaar deze haat jegens Leiden? Universiteitshistoricus Willem Otterspeer schreef een boek over onze universiteit in oorlogstijd, gebaseerd op bijzonder, persoonlijk…

Bij het Beleg van Leiden, in 1574, stierf een derde van de bevolking. Nog jaarlijks herdenkt de stad het einde van deze belegering met hutspot, haring en wittebrood. En Leiden staat niet alleen: steden zijn al duizenden jaren het toneel van strijd.

Hoe ontwikkelde het Nederlandse vluchtelingenbeleid zich in een periode waarin opeenvolgende coalitiekabinetten verantwoordelijk waren voor dit beleid tijdens vluchtelingencrises tussen 1913 en 2017, en welke overwegingen kunnen deze ontwikkeling verklaren?

The global agri-food system plays a critical role in food security and environmental issues.

Op 8 juli 2020 verdedigde Andres Sarmiento Lamus zijn proefschrift 'The Proliferation of Dissenting Opinions in International Law'. Het promotieonderzoek is begeleid door promotoren prof.dr. L.J. van den Herik en prof.dr. Y.A.A.S. Radi (UCLouvain).

The coursework within the Science Communication and Society (SCS) specialisation prepares students for internships and a career in communication about science and health.