Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

Promotor: W.T. de Groot

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

Promotor: R. Cramer

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Promotor: J. Aarts

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Globally and regionally, biodiversity is declining and there are shifts in species’ occurrences and functional traits.

Supervisor: P.J.J. Hooykaas

Plastics have become an integral part of modern society due to their versatility and durability.

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

This thesis investigates catalytic reactions at the atomic scale using scanning tunneling microscopy (STM), with a focus on Fischer–Tropsch synthesis, a key industrial process that converts hydrogen and carbon monoxide into liquid fuels.

This thesis investigates innovative and classical strategies in glycoconjugate vaccine development to address the growing threat of multidrug-resistant bacterial infections.

Anionic particles play an important role in biological systems where they fulfil many essential functions for cells.

This thesis aims to develop model-based approaches to optimize drug dosing in patients with overweight and (morbid) obesity.

In this thesis the links between allergy and intestinal health, the gut microbiome (GM), and external factors were studied by exploring the metabolome in longitudinal clinical studies and in vitro models.

Wat zijn de vaak onzichtbare cognitieve gevolgen van multiple sclerose? Die bracht Maureen van Dam tijdens haar promotieonderzoek in kaart. ‘De lichamelijke symptomen zien mensen meestal wel, maar de cognitieve symptomen verdienen minstens net zoveel aandacht.'

Wat levert een tweede taal spreken allemaal op, waarom leert de één makkelijker een tweede taal dan de ander en is een dialect ook een eerste taal? De Universiteit Leiden organiseert op 20 mei het Engelstalige publiekssymposium Twee Talen - één BeTalen, over tweetaligheid.

U kunt bij ons terecht als u vragen of zorgen heeft over de ontwikkeling van uw kind in de leeftijd van 0 tot 21 jaar.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

In this project of the Center for Public Values & Ethics (CPVE) ongoing research is conducted on the history of advice to Dutch central government by so-called State committees from 1814 to 2014. State committees have been installed by Dutch central government since 1814 to provide expert advice, research…

Promotores: G.A. Persoon, H.H. de Iongh

A single self-assembled semiconductor quantum dot in a high-finesse optical microcavity - the subject of this thesis - is an interesting quantum-mechanical system for future quantum applications. For instance, this system allows trapping of an extra electron and thus can serve as a spin quantum memory,…

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Prof.dr.ir. H.H. de Iongh

Promotor: Prof.dr. H.S. Overkleeft

Promotor: J.W. van Holten

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

In-use stocks of products can be considered as intermediaries between human needs and the physical world.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Als een nieuwe methode is ontwikkeld om een (neuro-)psychologische aandoening of hieraan gerelateerde gedragsfactoren te herkennen en te behandelen, kan deze nog niet direct in de klinische praktijk worden ingezet. Eerst moet de methode geëvalueerd worden, bij voorkeur in gerandomiseerde, gecontroleerde…

Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Understanding how nature captures and transfers solar energy is essential both for elucidating biological photosynthesis and for guiding the design of artificial light-harvesting systems.

In this thesis, Quantum computing, norms, and polynomials, we investigate the interplay between quantum mechanics, complexity theory, and functional analysis, three central areas of physics, computer science, and mathematics, respectively.

Adenosine diphosphate ribosylation (ADP-ribosylation) is a fascinating post-translational modification (PTM) that plays a role in a variety of cellular processes and is associated with several diseases, including cancer and viral infections.

During the development of the (human) body from a single fertilized egg, organs and structures must form. The development and growth of biological forms is called morphogenesis.