This thesis investigates opinion dynamics on random graphs through the lens of the voter model, a classical interacting particle system used to describe how consensus emerges in networks.

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

In this thesis, rational points on K3 surfaces are studied. In the first part of Chapter 1 the Brauer group and the the Brauer-Manin obstruction are introduced.

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

Thirty years ago, mutations in the BRCA1 gene were first linked to hereditary breast and ovarian cancer, establishing a genetic basis for cancer development.

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

De staf van het Instituut voor Wijsbegeerte bestudeert alle aspecten van de filosofie. In ons onderzoek streven wij naar een vruchtbare interactie tussen systematische en historische benaderingen van de filosofie. Wij werken in een context van intensieve nationale en internationale samenwerking.

Gibbs measures, as used in Statistical Mechanics, have a definition that is remarkably similar to the definition ofg-measures, used in dynamical systems.

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

Control of infectious diseases poses continuous challenges for human health.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Prof.dr. J. Memelink

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Promotor: Prof.dr. C.W.J. Beenakker

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

This thesis studied in depth the energy use and CO2 emissions of the industrial sector in China.

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

Consequences for sediment stability and seston trapping

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

The name ‘Jambi flora’ refers to fossil plants found as part of a rock formation from the Early Permian (296 million years old), located in the Jambi Province of Sumatra, Indonesia.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort

Humanity stands at a pivotal juncture, facing the dual challenge of environmental sustainability and rapid population growth, projected to exceed 11 billion by century’s end.

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

One of the most important correlation functions in physics, especially in cosmology, is the energy density, which describes how much energy is present at each point in spacetime due to matter fields. A key contribution to the energy density of the primordial universe comes from gravitational waves (GWs),…

Promotores: J. Jonkers, K.E. de Visser

In this thesis, the role of plant-mediated soil legacy effects in shaping aboveground plant-insect interactions was investigated.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

The unit residue group, to which the present thesis is devoted, is defined using the norm-residue symbol, which Hilbert introduced into algebraic number theory in 1897.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.