How were the Russians, under early modern conditions, able to incorporate this distant, undeveloped and, because frequent nomadic attacks, dangerous territory? And what role did the Kolyvan-Voskresensk plants play in this process?

Lezing, Tuesday Talk

Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

In this thesis, the role of plant-mediated soil legacy effects in shaping aboveground plant-insect interactions was investigated.

Promotor: Prof.dr. J. Kuiper

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Humanity stands at a pivotal juncture, facing the dual challenge of environmental sustainability and rapid population growth, projected to exceed 11 billion by century’s end.

An Active Galactic Nucleus (AGN) is a highly luminous region at the center of a galaxy, powered by the accretion into a supermassive black hole and emitting energy from radio waves to gamma rays, often outshining the host galaxy.

The expedition commanded by Nicolas Baudin to Tenerife, Mauritius, Australia, Timor and South Africa in 1800-1804 is fully researched in regard to ornithology.

Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

Catharanthus roseus (Madagascar periwinkle) produces valuable monoterpenoid indole alkaloids (MIAs) such as vincristine and vinblastine, crucial for cancer treatment.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

This thesis is about the study of hydrocarbons via infrared spectroscopy.

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

Cardiovascular syndromes are the major cause of death in Western societies.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

In this thesis, I focused on studying the above- and belowground interactions of J. vulgaris from a plant-soil feedback (hereafter, PSF) perspective. I investigated the temporal variation of negative PSF and examined the effects of root-associated bacteria on plant performance and aboveground herbiv…

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

Promotor: J. A. Bouwstra

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

This thesis studied in depth the energy use and CO2 emissions of the industrial sector in China.

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Promotores: Prof.dr. G. Miley & Prof.dr. J.M. van den Broek

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

The name ‘Jambi flora’ refers to fossil plants found as part of a rock formation from the Early Permian (296 million years old), located in the Jambi Province of Sumatra, Indonesia.

Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

International trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental improvements, while the opposite may be occurring.

This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Promotor: A. Kros

Op 28 oktober 2021 verdedigde Hein van der Bruggen zijn proefschrift en behaalde daarmee de doctorstitel.