Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

Zo’n 400 promovendi verdedigen elk jaar hun proefschrift aan de Universiteit Leiden, verdeeld over alle disciplines die de universiteit rijk is.

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

Promotor: Prof.dr. J. Kuiper

I have studied the hot, diffuse gas around and between galaxies. Specifically, I have used the EAGLE numerical simulations of galaxy formation to predict the properties of this gas, and I have used those properties to predict specific observables: soft X-ray absorption and emission lines.

Surface plasmons (SPs) are surface waves at the interface between a dielectric and a good metal, and are formed by the interaction between light and the free electrons at the metal-dielectric interface. They provide strong field confinement for optical fields, opening new possibilities for enhanced…

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

Promotores: Prof.dr. F.S. de Boer, Prof.dr. J.J.M.M. Rutten (Radboud Universiteit Nijmegen)

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Welk effect heeft een verwerkingsvoorkeur op de omgang met regels?

Is de kwaliteit van het huidige toezicht en handhaving door de overheid dusdanig dat hiermee de bedrijven die met grote hoeveelheden gevaarlijke stoffen werken tot naleving van de wet- en regelgeving worden gebracht?

Het essay Voor de vooruitgang verschijnt ter gelegenheid van de 450e Dies Natalis van de Universiteit Leiden. In 2025 vieren we ons 450-jarig bestaan. Thema van dit lustrum is De tijd vooruit.

Workshop

Workshop

Studievoorlichting, Online Experience

Kunst en vrije tijd, Kunst en vrije tijd

Workshop

De jaarlijkse dodenherdenkingen op de Dam en Waalsdorpervlakte, de Nederlandse excuses voor het slavernijverleden en de Cleveringa-oratie zelf: onze omgang met de geschiedenis is vaak vooral ritueel, vertelt Cleveringahoogleraar Frank van Vree die op 27 november zijn oratie uitspreekt.

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

Promotor: Prof. dr. A.G.G.M. Tielens

Automated Machine Learning (AutoML) is widely used to automatically build a suitable practical Machine Learning (ML) model for an arbitrary real-world problem, reducing the effort of practitioners in the ML development cycle for real-world applications. Optimization is a key part of a typical AutoML…

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Radio jets are important to the evoultion of galaxies. However, it is still not fully understood how a radio jet can be triggered.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

Promotor: Prof.dr. M. Ubbink

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.