Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

In this thesis,

Promotor: J. N. Kok, Co-promotor: A. J. Knobbe

This dissertation combines the use of defined microenvironments, high-resolution fluorescence microscopy, and time-resolved analysis, to study intracellular and cellular motility.

Argumentatie en retorica is het onderzoek naar hoe we iemand verbaal overtuigen. Oftewel, wat zeggen we en hoe zeggen we het?

Onze AI-wetenschappers werken nauw samen met onder andere de TU Delft en de Erasmus Universiteit.

Humans can see the world through the eyes of other humans and imagine what they know, want, and intend. This competence is known as Theory of Mind.

Promotor: J. Zaanen, Co-Promotor: V. Juricic

De Honours Academy biedt extra ontwikkelmogelijkheden aan studenten en docenten van de Universiteit Leiden.

Het essay Voor de vooruitgang verschijnt ter gelegenheid van de 450e Dies Natalis van de Universiteit Leiden. In 2025 vieren we ons 450-jarig bestaan. Thema van dit lustrum is De tijd vooruit.

Promotores: Prof.dr. F.S. de Boer, Prof.dr. J.J.M.M. Rutten (Radboud Universiteit Nijmegen)

Is de kwaliteit van het huidige toezicht en handhaving door de overheid dusdanig dat hiermee de bedrijven die met grote hoeveelheden gevaarlijke stoffen werken tot naleving van de wet- en regelgeving worden gebracht?

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Welk effect heeft een verwerkingsvoorkeur op de omgang met regels?

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Workshop

De jaarlijkse dodenherdenkingen op de Dam en Waalsdorpervlakte, de Nederlandse excuses voor het slavernijverleden en de Cleveringa-oratie zelf: onze omgang met de geschiedenis is vaak vooral ritueel, vertelt Cleveringahoogleraar Frank van Vree die op 27 november zijn oratie uitspreekt.

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Promotor: Prof. dr. A.G.G.M. Tielens

Automated Machine Learning (AutoML) is widely used to automatically build a suitable practical Machine Learning (ML) model for an arbitrary real-world problem, reducing the effort of practitioners in the ML development cycle for real-world applications. Optimization is a key part of a typical AutoML…

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.

Radio jets are important to the evoultion of galaxies. However, it is still not fully understood how a radio jet can be triggered.

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Promotor: Prof.dr. M. Ubbink

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Op 23 februari 2022 verdedigde Cale Davis het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. C. Stahn en dr. J.C. Powderly.

Diverse types of exoplanets such as gas giants on close-in orbits (hot Jupiters) and young massive giants on wide orbits (super Jupiters), with no analogs in the Solar System, pose challenges but also opportunities to our understanding of planet formation and evolution.

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Studievoorlichting

Tijdens een symposium ter ere van zijn 60ste verjaardag ontving statisticus Aad van der Vaart de koninklijke onderscheiding Ridder in de Orde van de Nederlandse Leeuw. Collega’s vertellen over zijn betekenis voor de statistiek en over hoe zij hem leerden kennen. ‘De samenwerking met Aad hoort tot de…

Graduate students at Central European University and the University of Vienna invite abstracts from MA and PhD students in the fields of Late Antique and Byzantine Studies for a graduate conference with the theme 'Receiving Byzantium, Byzantium Receiving' (16-17 May 2025, Vienna).

GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.

Lezing, Oort lecture