Dit programma heeft tot doel de gedigitaliseerde archiefbronnen van de archieven van Kerala en Tamil Nadu toegankelijker te maken voor Indiase en internationale wetenschappers en voor een zo breed mogelijk publiek, in het bijzonder voor de bevolking van Kerala.

Nieuw onderzoek van de National University of Singapore en Leiden laat zien dat chimpansees en bonobo’s net zoveel contrast in hun ogen hebben als mensen, waardoor ze gemakkelijk de richting van iemands blik kunnen volgen.

Explore how cultural heritage can proactively respond to global crises, from geopolitical conflicts to climate change, through innovative cross-cultural collaboration between Latin American stakeholders and Una Europa.

Do you want your research to fit the rubric of heritage? Is heritage a relevant concept here? These were some of the questions that came up in the lively discussion following twelve five-minute pitches given by Leiden researchers at the ‘Academic Open Mic’ workshop in the Lipsius building on Thursday…

Europese burgers worden geconfronteerd met uitdagingen op het gebied van globalisering, migratie, technologische ontwikkelingen en klimaatverandering. Deze uitdagingen vergen het uiterste van onderlinge internationale en intergenerationele solidariteit, wat rechtstreeks betrekking heeft op de grondslagen…

Promotor: H.J.M. de Groot

Consequences for sediment stability and seston trapping

Carbonaceous asteroids preserve a record of early solar system processes, where minerals and organic molecules, like polycyclic aromatic hydrocarbons (PAHs), offer clues to planetary evolution and prebiotic chemistry.

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

In a typical glycosylation reaction, a donor is activated to form a (variety of) electrophilic species which can react with a nucleophilic acceptor, following a reaction mechanism having both SN1 and SN2 character.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Promotor: W. Jiskoot, Co-promotor: H.A. Every

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Inspired by natural photosynthesis, perovskite-based photoelectrochemical (PEC) systems are being developed for artificial photosynthesis, aiming to enhance solar-to-hydrogen conversion for green energy.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Electron microscopy has become an extremely important techniquein a wide variety of elds.

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

Striga hermonthica, commonly known as witchweed, infests major cereal crops in Sub-Saharan Africa causing severe yield losses and threatening the livelihood of millions of resource poor farmers.

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.