In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

Fundamental research in the ALgebra, Geometry And Number Theory

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.

Promotor: P.D. Grünwald

Artful Mathematics: The Heritage of M. C. Escher

Nowadays, it is well known that hydrogen and helium (and small traces of lithium and beryllium) were created shortly after the Big Bang, while the heavier elements are created in the cores of stars at different evolutionary stages. When these stars explode as supernovae, they expel metals synthesised…

Human civilization consumes a huge amount of fossil fuels, which has resulted in an atmospheric CO2 level which has not been higher in over 800 millennia.

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing.

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Promotor: Prof.dr. C.W.J. Beenakker

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Promotor: Prof.dr. J. Kuiper

We consider the propagation of electrical signals through nerve fibres.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Promotor: Prof.dr. W.J.G.M. Peijnenburg

Heart failure is a major health care problem with high mortality.

Plant diversity is essential for us and our planet as it sustains the stability of our ecosystems, provides vital materials and food to us and supports many ecosystem services.

This dissertation is about Bayesian learning from data. How can humans and computers learn from data?

The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

De meeste kinderen leren pas op de middelbare school Frans. Hoe leuk is het als ze al wat Franse woorden leren en kennismaken met de Franse cultuur op de basisschool? Dat kan via deze kennismakingslessen, gemaakt door studenten van de Universiteit Leiden.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Empirical Legal Studies in Leiden focust op het bouwen van een interdisciplinaire gemeenschap van rechtsgeleerden en sociale wetenschappers die samen juridische vraagstukken onderzoeken op het snijpunt van recht en gedrag, waarbij diverse soorten methoden worden gebruikt.

Stellar feedback is a crucial ingredient in the evolution of galaxies.

Understanding how galaxies form, interact, and evolve comes largely from comparing theory predictions with observational data. Numerical simulations of galaxies provide the most accurate approach to testing the theory, as they follow the non-linear evolution of gas and dark matter in great detail and…

Promotor: J.N. Kok, Co-promotor: M.S. Lew

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

Cardiovascular syndromes are the major cause of death in Western societies.

This thesis is about the study of hydrocarbons via infrared spectroscopy.

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

Low-mass main-sequence stars like our Sun are continuous sources of outflowing hot magnetised plasma. In the case of the Sun, this is known as the solar wind, whereas for other stars they are called stellar winds.

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer