Recentelijk is een Special Issue van de European Journal of Criminology verschenen, die is samengesteld door Marieke Liem, Universitair Docent Criminologie bij het Instituut voor Strafrecht & Criminologie, en William Pridemore.

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

This dissertation, Layered Loyalties: The Natuurkundige Commissie in the Netherlands Indies (1820-1850), studies the Natuurkundige Commissie.

Promotor: H.V.J. Linnartz

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Promotores: G.W. Canters, T.J. Aartsma

Promotor: Prof.dr. E Gittenberger, Co-Promotores: C.H.J.M. Fransen, B.W. Hoeksema

This thesis studies the geometry of representation varieties and character stacks. These are spaces parametrizing the representations of a finitely generated group, typically the fundamental group of a compact manifold, into an algebraic group G.

This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

This thesis involves three topics: benchmarking discrete optimization algorithms, empirical analyses of evolutionary computation, and automatic algorithm configuration.

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

Humans can see the world through the eyes of other humans and imagine what they know, want, and intend. This competence is known as Theory of Mind.

Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Surface acoustic waves (SAWs) are mechanical waves that travel along the surface of a material and find many applications in modern technologies due to the ease of excitation on piezoelectric substrates via interdigital transducers (IDTs).

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

Promotores: F.H. van Lunteren, F.P. Israel

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

Promotor: A. Kros

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

Promotor: Prof.dr. J. Kuiper

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Promotor: B.van de Water, Co-promotor: L.S.Price

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Spectroscopic studies on fluorescent single molecules in organic condensed matter does not only provide information about the molecule itself, but also its near environment. By suppression of phonon-induced broadening of spectral lines through cooling to low temperatures, small changes in the spectral…

Producing green energy has become the main goal in our society in the search of reducing or eliminating the carbon emission from fossil fuels.

Promotor: Prof.dr. T.H.W. Bäck

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

This thesis is a (biased) journey through very different topics in astrophysics: quasars and new populations of active galactic nuclei, gravitational waves from merging black holes, and protoplanetary discs around young stars.

We have conducted a full spectral line survey of the 3-13 micron region of two massive protostars, AFGL 2591 and AFGL 2136, for the first time at high spectral resolution.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Promotor: J. Aarts

In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).

When observing star-forming galaxies, we are not only seeing stellar light, but we also see how this interacts with galactic gas and dust. This thesis contains studies of the stellar, nebular and dust properties of low mass star-forming galaxies.

Promotor: Prof.dr. S. Portegies Zwart