813 zoekresultaten voor “organic india di singapore” in de Publieke website
-
Synthesis of mycobacterial phenolic glycolipids
Het proefschrift omschrijft de chemische synthese van fenolische glycolipiden van verschillende mycobacteriën met het doel om deze te kunnen gebruiken voor immunologisch onderzoek.
-
A bioorthogonal chemistry approach to the study of biomolecules in their ultrastructural cellular context
In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.
-
Inhibitors and probes targeting endo-glycosidases
The chemical synthesis of inhibitors and probes targeting endo-glycosidases.
-
Design and synthesis of next generation carbohydrate-mimetic cyclitols: towards deactivators of inverting glycosidases and glycosyl transferases
Synthetic methodlogy is described, aiding in the synthetic preparation of putative inhibitors of retaining and inverting glycosidases and glycosyl transferases. All constructs are cyclophellitol-based cyclitols.
-
all’italiano odierno: cinque secoli di lingua e stile Simposio per il cinquecentenario delle Prose della volgar lingua di Pietro Bembo (1525–2025)
Congres/symposium
-
Mining the kinematics of discs to hunt for planets in formation
Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…
-
Targeting of antigen-presenting cells with mannosylated conjugates
This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.
-
The use of activity based protein profiling to study proteasome biology
Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea
-
Wild versus domestic prey in the diet of tigers
A recent study on reintroduced tigers in Panna Tiger Reserve in India reveals that risks from tigers increased more because of human behaviour and people's livestock husbandry practices.
-
a 'Trailing Spouse': Migrant women, space, body and belonging in Singapore
Promotie
-
Explorations of Water Oxidation Catalysis in Explicit Solvent
In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.
-
Photothermal studies of single molecules and gold nanoparticles: vapor nanobubbles and conjugated polymers
Promotor: M.A.G.J. Orrit
-
Self adjuvanting immunopeptides: Design and synthesis
Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.
-
NMR Faciliteit
Met de NMR faciliteit doen we onderzoek naar de synthese van paramagnetische moleculen om kennis te vergaren over de structuur en dynamiek van eiwitten. Deze kennis kan dienen als basis voor een medicijn dat zich hecht aan een eiwit of voor de ontwikkeling van vaccins. Medicijnontwikkeling is één van…
-
Linking the gene regulatory network with the functional physical structure of whole-genome engineered Arabidopsis mutants : an HR-MAS NMR-based
Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.
-
Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
-
Startfinanciering
Una Europa organiseert regelmatig oproepen voor startfinanciering, ook wel 'seed funding' genoemd. Universiteit Leiden biedt vaak extra financiering aan voor projecten waaraan Una Europa-universiteiten meedoen.
-
VIVAS by Angélica Cruz Aguilar
Orange the World 2025
-
Even voorstellen: de studenten van Cosmopolis Advanced
In juli is het nieuwe masterprogramma Cosmopolis Advanced van start gegaan, een initiatief van het Instituut voor Geschiedenis van de Universiteit Leiden en Universitas Gadjah Mada (UGM) in Yogyakarta. Het onderzoeksprogramma Cosmopolis Advanced, geleid door prof.dr. Jos Gommans en coördinator dr. Lennart…
-
Synthetic peptides, nucleic acids and molecular probes to study ADP-Ribosylation
This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.
-
Core cross-linked polymeric micelles based on polypept(o)ides: from secondary structure formation of polypeptides to functional cross-linking
This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.
-
Synthesis of cyclic peptides as bioconjugation platforms
Cyclic peptides are investigated as a platform to induce different orientations between various ligands.
-
Chemical synthesis of fragments of galactosaminogalactan and pel polysaccharides
The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.
-
Mechanism-based inhibitors and probes for neuraminidases
Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.
-
The development of molecular tools for investigating NAD+ metabolism and signalling
Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…
-
Nicolas Blarel
Faculteit der Sociale Wetenschappen
-
Het Groothertogdom Litouwen en de Gouden Horde
Did the Jochids leave their mark on the Grand Duchy, taking into account that the Lithuanian state was one of the main successor states of the Great Horde in the 16thCentury?
-
Burgerschap: identiteitsvorming door geschiedschrijving
Steeds meer burgers in Azië hebben behoefte om een sterke eigen identiteit te vormen. Dat komt onder meer door mondialisering en het besef dat Aziatische landen zoals China en India uitgroeien tot nieuwe wereldmachten. Hoogleraar Hilde De Weerdt onderzoekt hoe in China politieke ideeën en nationale…
-
South and Southeast Asian Studies (BA)
Ben jij nieuwsgierig naar landen als India, Indonesië, Nepal of Thailand? Wil je een taal leren zoals Hindi of Indonesisch, en je verdiepen in de rijke culturen, geschiedenis en actualiteit van deze fascinerende regio? Dan is de (Engelstalige) opleiding South and Southeast Asian Studies aan de Universiteit…
-
De tijdbesteding en sociale netwerken van kinderen
-
-
De technologieën van mondiale migratie
Technologische vooruitgang heeft impact op ons dagelijks leven. Ze zijn ook door regeringen ingezet om de grensbeveiliging te beheren, vooral bij controversiële grensovergangen. Hekken, hittesensoren, hittecamera’s, drones en andere hoogtechnologische apparatuur die momenteel worden getest, produceren…
-
Influence of the electrode-electrolyte interface on electrochemical CO2 reduction reaction and hydrogen evolution reaction
The goal of this thesis is to understand how interfacial parameters, such as the addition of organic additives, bulk pH or metal cations of the electrolyte, affect the relevant electrocatalytic reactions, i.e. electrochemical CO2 reduction reaction or hydrogen evolution reaction.
-
Towards in-cell structural study of light-harvesting complexes : an investigation with MAS-NMR
Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.
-
Kunstmatige fotosynthese
Voor de omzetting van zonlicht naar brandstof
-
Coherent dynamics in solar energy transduction
Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda
-
Photocatalytic approaches for carbon-heteroatom bond construction
hotocatalysis has emerged as a powerful tool for enabling challenging transformations in organic synthesis. This thesis explores the development of several photocatalytic reactions designed to form carbon-heteroatom bonds from less-functionalized precursors.
-
Bioorthogonal deprotection strategy to study T-cell activation and cross- presentation
Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.
-
Synthesis of well-defined ADP-Ribosylated biomolecules
Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov
-
Synthesis and applications of cell wall glycopolimer fragments from Staphilococci and Enterococci
Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…
-
The synthesis of mannose-derived bioconjugates and enzyme inhibitors
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee
-
Enzyme-substrate interactions in the processive enzyme xylanase
The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.
-
Inverse electron demand Diels-Alder pyridazine elimination: synthetic tools for chemical immunology
The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…
-
Development of synthetic procedures towards immunostimulating carbohydrates
Promotor: Prof.dr. G.A. van der Marel, Co-Promotor: J.D.C. Codée
-
Cyclophellitol and its derivatives: synthesis and application as beta-glycosidase inhibitors
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
-
Activity-based proteomics of the endocannabinoid system
This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.
-
Institute for Chemical Immunology
Overkleeft
-
Towards the development of synthetic vaccines against tuberculosis
The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.
-
Design and Synthesis of Inhibitors and Probes for Sulfoquinovosidases and Xylanases
This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.
-
Design, synthesis, and evaluation of antigenic peptide conjugates containing Toll-like receptor agonists
This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.
-
Belangen van staten: inzicht in wereldpolitiek
Alle spelers op het wereldtoneel opereren strategisch om hun belangen veilig te stellen. Politicologen aan de Universiteit Leiden maken dit grillige krachtenspel inzichtelijk. Hun onderzoek helpt kiesgerechtigden, Ngo’s, overheden en internationale organisaties om slimme keuzes te maken in een complexe…