De Leiden Institute for Brain and Cognition (LIBC) Publieksdag, met als thema 'geheugensporen', trok ruim 700 bezoekers.

Tot wel 50% van de mensen met de ziekte van Parkinson ontwikkelt na verloop van tijd cognitieve achteruitgang; deze studie onderzoekt het gebruik van ‘oefeneffecten’ op neuropsychologische tests als een vroege voorspeller van cognitieve achteruitgang.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

Promotor: Prof.dr. T. Schmidt

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

Heart failure is a major health care problem with high mortality.

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

Cardiovascular syndromes are the major cause of death in Western societies.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

This thesis discusses several questions regarding the double ramification cycle as a Chow class on the moduli space of stable n-pointed genus g curves using tools from so-called logarithmic geometry.

Promotor: Prof.dr. G.P. van Wezel

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

Promotor: Prof.dr. E. F. van Dishoeck

Promotor: Prof.dr. J. den Hertog

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Promotor: A.W. van der Vaart

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez.

Onder vindt u de wetenschappelijke publicaties van het Navigatie Lab Leiden

Factoren van invloed op arbeidsparticipatie onder mensen met multiple sclerose

In het Leids Universitair Behandel- en Expertise Centrum (LUBEC) werken Klinisch (neuro)Psychologen, GZ-psychologen en Orthopedagoog-Generalisten. Zij bieden multidisciplinaire diagnostiek op maat.

Het LIBC is actief betrokken bij training & onderwijs op het gebied van hersenen en cognitie.

This course explains the functions of each international court and tribunal in The Hague. On the basis of cases and interviews with judges and lawyers, this course explores the role of these courts and tribunals and their potential to contribute to global justice.

The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.

Artificial intelligence algorithms govern in subtle, yet fundamental ways, the way we live and are transforming our societies. The promise of efficient, low‐cost or ‘neutral’ solutions harnessing the potential of big data has led public bodies to adopt algorithmic systems in the provision of public…

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

The studies in this thesis are focused on the physical effects in the flat band materials. The results contain the discovery of strong enhancement of RKKY spin-spin interactions with specific geometric arrangement and dynamical generation of excitonic order parameter with high magnitude.

Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.

Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

Programma's die de symptomen van sociale angst bij kinderen willen verminderen, omvatten doorgaans meerdere onderdelen, zoals blootstelling en mentale herstructurering. Het is onbekend of afzonderlijke onderdelen positieve effecten opleveren bij kinderen of dat een combinatie van onderdelen nodig is…

Human vocal communication and music perception represent advanced cognitive skills, seemingly innate and universal. These faculties encompass a range of perceptual and cognitive abilities. Cross-species research sheds light on the origins of musicality by investigating whether these traits are shared…

De psychologen Fenna Poletiek en Erik de Kwaadsteniet krijgen van vakbond FNV een subsidie om te onderzoeken hoe mensen zich gaan gedragen ten opzichte van werk als ze een basisinkomen krijgen. Hoe gaan ze op zoek naar een antwoord?

Promotie

Meer begrip van neurodiversiteit en een inclusieve, stimulerende werkomgeving voor iedereen.