Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

This dissertation aims to advance understanding of amoeboid single cell migration under the influence of changing physicochemical environmental properties. The particular focus is on the relatively unknown influence of differing physical properties in the extracellular environment, such as the migratory…

Promotor: S.J. Edixhoven Co-promotor: L. van Geemen, P. Parent

This thesis covers various applications of topology in condensed matter physics and quantum information.

This thesis contributes to studying primordial cosmology theories and their detectability in future observations.

Promotor: S.J. Edixhoven, Co-promotor: K.J. Batenburg

Promotor: Prof.dr. E.J.J. Groenen, Co-Promotor: M. Huber

Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…

Quantum computers are a proposed fundamentally new type of computer. They aim to perform some computations much faster than previously possible by exploiting phenomena at the quantum scale, called superposition and entanglement.

During the course of drug discovery translational steps are made.

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

Plastics are an intrinsic part of our society. Annually, 400Mt of plastics are produced of which roughly 40% is discarded within a year.

Hieronder vind je de antwoorden op een aantal veelgestelde vragen over toelating tot de klinische specialisaties van de Master Psychologie.

Combinatorial games are games for two competing players, moving in a turn-by-turn fashion, in which there is no chance nor hidden information⁠. Chess, checkers and the simpler tic tac toe are well-known examples of this class of games, as well as game of go⁠.

Supervisor: P.J.J. Hooykaas

Studievoorlichting

Voor een veilige, duurzame en veerkrachtige maatschappij is het nodig om tegengestelde belangen te overbruggen. Onderzoekers aan de Universiteit Leiden bestuderen hoe individuen, groepen en staten zich hierbij gedragen. Met die kennis dragen ze bij aan gelijkwaardigheid binnen en tussen samenlevinge…

Interactive exploration of large volumes of data is increasingly common, as data scientists attempt to extract interesting information from large opaque data sets. This scenario presents a difficult challenge for traditional database systems, as (1) nothing is known about the query workload in advance,…

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Promotie

Als student aan de Universiteit Leiden maak je deel uit van Una Europa: een alliantie van elf vooraanstaande universiteiten. Daarmee heb je toegang tot een bruisende internationale gemeenschap met tal van mogelijkheden om te studeren, werkervaring op te doen en je leiderschapsvaardigheden te ontwikk…

Grensverleggend geschiedenis leren.

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

Promotor: C. W. J. Beenakker, Yu. V. Nazarov, Co-promotor: J. Tworzydlo

Promotor: Prof.dr. S. Haring

With the dramatic growth of the image data on the web, there is an increasing demand of the algorithms capable of understanding the visual information automatically.

Promotor: K.E. Schalm, Co-promotor: S.S. Lee

Patterned detectors are an existing technology that can be found in almost all color cameras.

Promotor: S.M. Verduyn Lunel

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

The theoretical explanation of cosmic acceleration is nowadays one of the biggest puzzles in cosmology.

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.

Promotores: Prof.dr. F.S. de Boer, Prof.dr. J.J.M.M. Rutten (Radboud Universiteit Nijmegen)

The expedition commanded by Nicolas Baudin to Tenerife, Mauritius, Australia, Timor and South Africa in 1800-1804 is fully researched in regard to ornithology.

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Big Science, commonly defined as conventional science made big in three dimensions, namely organizations, machines, and politics, brings a plethora of different stakeholders together, often for a long period of time. This includes policymakers, scientists, (scientific) managers as well as local “host”…

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Promotor: Prof.dr. P. Stevenhagen, Co-promotor: B. de Smit

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

Taxonomy as a science has accumulated data and knowledge for more than 250 years.

Promotores: Prof.dr. S.J. Edixhoven, Prof.dr. E. Ullmo (University Paris-Sud)

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

Promotor: A. Kros

Promotores: Prof.dr. H Lenstra, Prof.dr. A Facchini (Padova University)

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

The availability of indicators based on social media has opened the possibility to track the online interactions between social media users and scholarly entities.

This dissertation is organised into three parts, each addressing a distinct research area related to Gibbs measures.