In this thesis, single-cell approaches were applied to characterize the impact of aging on the immunological B cell landscape in different models of atherosclerotic cardiovascular disease, with the goal to identify and study new B cell-associated biomarkers and therapeutic targets to halt atherosclerosis…

In this thesis we study the moduli space of genus g curves, and the differential forms that occur naturally on this moduli space.

This thesis is is made of three parts. The first part describes a generalization of the Chabauty's method, that can be used to determine the rational points of a curve such that s+g>r+1, where g is the genusof the curve, r is the rank of the Mordell-Weil group of the jacobian of the curve and s is…

This thesis describes how different colours of light affect various aspects of the growth and development of Arabidopsis and tomato plants⁠.

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality⁠.

Prof.dr. P. Stevenhagen, Prof.dr. K. Belabas (Universite Bordeaux I)

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Promotores: H.W. Lenstra, A. Lucchini

Although plant domestication has significantly altered crop genetics and phenotypes, its effects on the taxonomic and functional diversity of plant-associated microbiomes are not well understood.

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

The zoo of detected exoplanets reveals both the uniqueness of our own Solar System and the complexity of planetary system formation, sparking fundamental questions about how planetary systems form and evolve.

To contribute to the body of knowledge aiming at a better coverage of ecosystem service assessment in LCA studies, this thesis dives into the challenges of incorporating existing ecosystem service methods within the impact assessment phase of the conventional LCA framework.

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

Promotor: J. N. Kok, Co-promotor: A. J. Knobbe

In astronomy, the interpration of observations and measurements plays a crucial role: we rely purely and fundamentally on the information that reaches us as observers. And 80% of all matter in the universe is undetectable directly.

This dissertation presents the synthesis and evaluation of antibody recognition for various capsular polysaccharide (CP) fragments of Staphylococcus aureus (S. aureus).

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

The physical origin of the dozens of stellar-mass binaries, the mergers of which have been detected by the LIGO-Virgo-KAGRA collaboration via gravitational waves, is still unknown.

This dissertation presents new cryptographic protocols, which can be divided into two families.

Promotor: J.W.M. Frenken

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

If X is a locally compact Hausdorff space, then a representation of the complex C* algebra C_0(X) on a Hilbert space $H$ is given by a spectral measure that takes its values in the orthogonal projections on $H$.

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

Promotores: E. van Dijk, G.R. de Snoo. Co-promotor: H. Staats

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

The ability to count is a property not often attributed to materials, despite the abundance of memory in materials. Regardless of how a material stores information, it is often difficult to retrieve exactly ‘what’ a material remembers.

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

This thesis deals with properties of Jacobians of genus two curves that cover elliptic curves.

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Wetlands provide many ecosystem goods and services which include fish production. The sustainability of small-scale fisheries (SSF) has received considerable attention in recent years because fish is one of the major sources of animal protein to a considerable fraction of the global population which…

Promovenda Luisa Prochazkova deed samen met haar collega's van cognitieve psychologie onderzoek naar de effecten van microdoseringen psychedelische drugs op creativiteit. Hun eerste voorzichtige conclusie: je wordt inderdaad creatiever van een klein beetje LSD.

African oral literatures, new media and technologies: challenges for research and documentation

Bernhard Hommel van de Universiteit Leiden en Reinout Wiers van de Universiteit van Amsterdam hebben een nieuw model ontwikkeld voor de controle van menselijk gedrag. Volgens de psychologen is ál ons gedrag doelgericht, maar maken we vaak gebruik van automatismen. Publicatie 14 november in Trends in…

In this dissertation, matching, entropy, holes and expansions come together. The first chapter is an introduction to ergodic theory and dynamical systems.

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Promotor: B. van de Water

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Beneficial plant-associated microbiota, particularly those inhabiting the rhizosphere, contribute substantially to plant health through pathogen suppression, stimulation of plant defence responses, and enhanced nutrient acquisition.

Quantum computing represents a fundamentally new computational paradigm, capable of addressing problems that are intractable for classical computers.

In this thesis we use state-of-the-art observations and simulations to provide the best constraints to date on the HVS ejection rate and constraints on the stellar content and dynamics at the GC, including the progenitor binary populations and their star formation history.