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The largest genus within the Phyllanthaceae family is a group called Phyllanthus L. Recent studies have shown, that Phyllanthus is paraphyletic with the genera Glochidion, Breynia and Synostemon nested within it.

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

The Sun and all the stars in the night sky reside in the Milky Way galaxy. In the at-rest reference frame of the Galaxy, typical stars travel with velocities of about 100-200 kilometres per second.

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

The RNA guided endonuclease based on the CRISPR/Cas system of Streptococcus pyogenus is a potent new tool for genome engineering in plants.

Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

Protoplanetary disks are the gas and dust environments where planetary systems form around young stars. Using observations from the Atacama Large Millimeter/submillimeter Array (ALMA) this thesis analyses the gaseous molecular reservoir, using multiple tracers to resolve the 3D structure of protoplanetary…

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

When a star is born in our Galaxy, it is quite likely that it has formed within a massive cluster, which hosts numerous high-mass stars bathing their lower mass neighbours in UV radiation.

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

Promotor: F. Arbab, R. De Nicola, Co-Promotor: M. Tribastone

Promotor: K.H. Kuijken

This thesis is about cosmological inflation and its relation to observations.

Promotor: Prof.dr. H.L.V. Linnartz

Quantum computers are a proposed fundamentally new type of computer. They aim to perform some computations much faster than previously possible by exploiting phenomena at the quantum scale, called superposition and entanglement.

My PhD research is devoted to studies of the conjectural cluster-algebraic symmetry in the theory of topological string, which is the simplest, however already non-trivial sector in the theory of string.

Een historische blik achter de betonnen schermen van de Amerikaans-Nederlandse betrekkingen.

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

Promotor: Prof.dr. M. Franx, Co-Promotor: Rychard Bouwens

This thesis studies operator-algebraic aspects of subproduct systems, a generalization of product systems of Hilbert spaces.

Rembrandtroute ter gelegenheid van het 444-jarig bestaan van de Universiteit Leiden en het Rembrandtjaar 2019. Met speciale dank aan Germanisches Nationalmuseum (Neurenberg), The Leiden Collection (New York), Museum De Lakenhal (Leiden), Mauritshuis (Den Haag), Rijksmuseum/Musée du Louvre (Amsterdam/Parijs),…

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

This thesis covers various applications of topology in condensed matter physics and quantum information.

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

This thesis mainly focuses on cross-modal retrieval and single-modal image retrieval via deep learning methods, i.e. by using deep convolutional neural networks.

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

This thesis concerns the relation bettween the good reduction of Shimura varieties and the associated loop groups.

This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.

Promotor: W. Jiskoot, Co-promotor: A. Kros

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

Humans share meaning through language. Over time, repeated interactions have shaped languages into forms that match our cognitive preferences, making them structured, expressive, easy to learn, and ultimately, meaningful.

Kijk mee en praat mee over de wetenschap van het verleden tijdens wekelijkse Let’s Plays van populaire games en vodcasts op het livestreamplatform Twitch.

Promotores: P. Stevenhagen, L. van Geemen Co-promotor: R.M. van Luijk

The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…

Dit project stelt het idee van een liberale Amerikaanse wereldorde ter discussie. Het onderzoekt hoe illiberale denkbeelden het buitenlands beleid van de VS vormden en wat dat betekent voor internationale politiek vandaag.

Tijdens het symposium ‘Transdisciplinary Study of Just Public Algorithmic Systems’, op vrijdag 24 maart in Den Haag, staat onderzoek naar het gebruik van algoritmische systemen in de publieke sector centraal. Een actueel onderwerp dat de laatste tijd veel in de belangstelling staat. Vijf vragen over…

Met de komst van socialemediakanalen als Twitter, Facebook en Instagram is het makkelijker dan ooit om informatie met elkaar te delen. Ook desinformatie. Tijdens zijn promotie ontwikkelde informaticus Xueqin Chen een nieuwe manier om nepnieuws te herkennen en te voorspellen hoe berichten zich binnen…

Het Instituut voor Geschiedenis feliciteert Manon van der Heijden met het verkrijgen van een VICI-subsidie voor het onderzoek 'Crime and Gender 1600-1900: a comparative perspective.'