674 zoekresultaten voor “site role” in de Publieke website
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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The Role of Humans in Surgery Automation
Eduard Fosch-Villaronga, Hadassah Drukarch en Bart Custers van eLaw - Centrum voor Recht en Digitale Technologie, onderzoeken met Pranav Khanna , eLaw alumnus, de invloed van automatisering op de interactie tussen mens en robot en verantwoordelijkheid bij chirurgische innovatie.
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Workshop Exploring the Role of Hype in the Future of Quantum Technology
Sensatieverhalen vertellen, voordelen overdrijven en risico's onderschatten: ergens een 'hype' over creëren klinkt niet als iets waar een verantwoordelijke wetenschapper zich aan zou wagen. Of kunnen we een hype ook op een 'goede manier' inzetten? Wat kunnen we bereiken door discussies over de quantumtoekomst…
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Navigating Between Principle and Pragmatism: The Roles and Functions of Atrocity-Related United Nations Commissions of Inquiry in the International
Op 7 november 2018 verdedigde Catherine Harwood haar proefschrift 'Navigating Between Principle and Pragmatism: The Roles and Functions of Atrocity-Related United Nations Commissions of Inquiry in the International Legal Order'. Het promotieonderzoek is begeleid door promotoren prof. dr. L.J. Van den…
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The role of glomerular filtration and active tubular secretion in predicting renal clearance in children using population pharmacokinetic and
In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.
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The Role of the Domestic Law of the Host State in Determining the ratione materiae Jurisdiction of Investment Treaty Tribunals: The Partial Revival
Op 19 december 2019 verdedigde Reza Eftekhar zijn proefschrift 'The Role of the Domestic Law of the Host State in Determining the ratione materiae Jurisdiction of Investment Treaty Tribunals: The Partial Revival of the Localisation Theory'. Het promotieonderzoek is begeleid door promotor prof.dr. E.…
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selective for human constitutive proteasome and immunoproteasome active sites
This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.
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The power of biotic ligand models : site-specific impact of metals on aquatic communities
Promotor: G.R. de Snoo, Co-promotores: M.G. Vijver, J.P.M. Vink
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Joachim Koops ontvangt Jean Monnet Chair ‘The EU’s Role in Security and Global Affairs’
Joachim Koops, Professor of Security Studies and Scientific Director of Leiden University’s Institute of Security and Global Affairs (ISGA) has been awarded a ‘Jean Monnet Chair’ with a focus on ‘The European Union’s Role in Security and Global Affairs’ (EURISGA).
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Andrea Evers’ role in the new Executive Board of PsychologyAndrea Evers’ role in the new Executive Board of Psychology
The new Executive Board of the Institute of Psychology became effective on 1 February 2022. Scientific director Andrea Evers tells us where she gets her energy from.
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“Leiden linguists play a key role in linguistics”
Van 2 tot 5 september 2015 is Leiden het toneel van een van de grootste linguïstische congressen ter wereld: de Societas Linguistica Europaea (SLE) Annual Meeting 2015. Hoe heeft Leiden zo'n prominente positie binnen de Taalkunde gekregen? Een gesprek met taalwetenschapper Arie Verhagen.
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The role of chemical weapons in the Ukraine conflict
Anneleen van der Meer bespreekt het vermeende gebruik van chemische wapens door Rusland in Oekraïne in The Conversation.
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Jiaxin ZhangFaculteit der Wiskunde en Natuurwetenschappen
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Exploring structure dependencies of gas-surface interactions with curved single crystals
Curved single crystals provide variable, but well-defined surface structures.
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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Lezing 'What is the role of the European Union in the world?' door Federica Mogherini
Donderdag 16 april jl. verwelkomde Campus Den Haag een belangrijke gast. De Italiaanse Federica Mogherini, Hoge Vertegenwoordiger van de Europese Commissie op het gebied van Buitenlandse Zaken en Veiligheidsbeleid bezocht Den Haag.
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Applications of Natural Deep Eutectic Solvents to Extraction and Preservation of Biomolecules
The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.
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Chemokine signaling mechanisms underlying inflammation and infection control: insights from the zebrafish model
This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.
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Anisotropy in cell mechanics
Mechanical interactions between cells and their environment play an important role in many biological processes.
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Targeted Informed consent: empowering young participants in medical-scientific research
Promotor: J.M. van den Broek Co-promotor: M.C. de Vries
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RNA splicing in breast cancer progression
In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.
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Functional analysis of Dof transcription factors controlling heading date and PPDK gene expression in rice
Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang
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Cognitive Bias in the Judgment of Business Valuations and Valuators
Op 1 april 2020 verdedigde Marc Broekema zijn proefschrift 'Cognitive Bias in the Judgment of Business Valuations and Valuators'. Het promotieonderzoek is begeleid door promotor prof. dr. J.I. van der Rest.
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Virus-host metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
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Volatile compounds from Actinobacteria as mediators of microbial interactions
Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.
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Asia and the UN
Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.
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Robert VerpoorteFaculteit der Wiskunde en Natuurwetenschappen
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Mechano-transduction mediated by integrin-based adhesion complexes: integration of cytoskeleton and adhesion dynamics
In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.
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Studies on molecular basics of metabolic syndrome in zebrafish
The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.
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Prosecutorial Discretion in International Criminal Justice
Op 23 februari 2022 verdedigde Cale Davis het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. C. Stahn en dr. J.C. Powderly.
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Imaging complex model catalysts in action
From surface science towards industrial practice using high-pressure scanning tunneling microscopy.
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Restoration of ditch bank plant diversity : the interaction between spatiotemporal patterns and agri-environmental management
Promotor: G.R. de Snoo, Co-promotor: C.J.M. Muster
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Essentiality of conserved amino acid residues in β-lactamase
Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.
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Improving targeted gene editing in Arabidopsis thaliana
Understanding DNA repair mechanisms is essential for advancing plant biotechnology and crop improvement. This study investigates how double-strand breaks (DSBs), induced by CRISPR/Cas systems, are repaired in the model plant Arabidopsis thaliana, and how these processes influence Agrobacterium tumefaciens…
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The resilience of tropical intertidal seagrass meadows, grazed by dugongs, and the impact of anthropogenic stressors
Seagrass is a marine flowering plant with special adaptations to coastal and marine environments, playing a crucial role in providing a wide range of ecosystem services.
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Shining Light on PAHs in Space
Polycyclic aromatic hydrocarbons (PAHs) are the most abundant class of organic compounds in space. The PAH field evolves from the constant interaction between experimentalists, theorists, modellers and observers. While laboratory research and quantum chemical calculations together set up the molecular…
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Cathodic corrosion
Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.
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Gintingan in Subang: An Indigenous Institution for Sustainable Community-Based Development in the Sunda Region of West Java, Indonesia
This study attempts to understand how indigenous community institutions pose an important role in sustainable community-based development, including the integration between local culture and development.
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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A time-space translation mechanism for patterning the vertebrate anteroposterior axis
My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.
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Stock-driven Scenarios on Global Material Demand
The role of material production as a driver of environmental impacts is increasing, which calls for a better understanding of global material flows. This thesis explores the role of in-use stocks of products, buildings and infrastructure as a key driver of global material demand and discusses the implications…
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Noonan and LEOPARD syndrome in zebrafish: molecular mechanisms and cardiac development
Promotor: Prof.dr. J. den Hertog
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Innate immune modulation in atherosclerosis and vascular
Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot
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Ecological functioning of bacterial chitinases in soil
Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)
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The symmetry of crystals and the topology of electrons
Promotor: J. Zaanen, Co-Promotor: V. Juricic
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Cellular Forces: Adhering, Shaping, Sensing and Dividing
Promotor: Prof.dr. T. Schmidt
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Destroy, Create, Transform and Sublimate. Laboratory Dissociation Studies on Polycyclic Aromatic Hydrocarbons and Analogues
The aromatic infrared bands (AIBs) seen throughout the interstellar medium (ISM) are generally thought to be carried by polycyclic aromatic hydrocarbons (PAHs) and their nitrogen analogues (PANHs).
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Genetic and environmental factors determining heterogeneity in preservation stress resistance of Aspergillus niger conidia
Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.
