The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.

International trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental improvements, while the opposite may be occurring.

The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Promotor: Prof.dr. E Gittenberger, Co-Promotores: C.H.J.M. Fransen, B.W. Hoeksema

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

Promotor: J. Zaanen

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

Promotor: Prof.dr. W.T.F. den Hollander

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

The overall theme of this thesis is to complement the electrochemical data acquired in fuel cell research with in situ X-ray photoelectron spectroscopy (XPS) and soft X-ray absorption spectroscopy (XAS).

Plastics have become an integral part of modern society due to their versatility and durability.

uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.

Voordrachten in het kader van het onderzoeksproject Zelfredzaamheid en sociale bescherming over de levenscyclus (aug. 2017 – dec. 2023).

The ultimate aim of this project (initiated by the European Law Institute) is to design a framework that will enable the further development of coherent and functional rules for business rescue in Europe.

Kunst en vrije tijd, Kunst en vrije tijd

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

De in de introductie geschetste ontwikkelingen leiden ertoe dat huishoudens meer verantwoordelijk gaan dragen voor sociale risico’s, meer zelf moeten plannen, over een langere periode en onder meer onzekerheid.Dit geldt niet alleen in Nederland, maar ook in andere westerse landen. Dit leidt tot de onderstaande…

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Promotor: Prof.dr. M. Ubbink

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Promotor: Prof.dr. G.J. Kroes

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

Hydrogen peroxide (H2O2) is an important bulk chemical that is used in various industrial processes. More than 95% of the H2O2 used in industry is made via the anthraquinone process during which a large amount of energy is going to waste.

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

The thesis deals with the study of giant radio galaxies (GRGs), which are radio galaxies of megaparsec sizes.

In this thesis, classes of strongly interacting quantum field theories, have been studied.

Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

This thesis consists of two subjects, that are both a consequence of radiation pressure.

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Debat

Op 14 oktober 2021 is het publieksboek uitgekomen. Sindsdien kunnen alle bestanden en links via deze website geraadpleegd worden.

This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.

Promotor: G.A. Persoon, Co-promotor: H.H. de Iongh

The Sundanese people, the largest ethnic group in West Java, have been using traditional medicine for a long time. Known as ubar kampung, Sundanese indigenous knowledge, beliefs and practices of traditional medicine are based on local people’s knowledge and use of Medicinal, Aromatic, and Cosmetic (MAC)…

Lezing

The confinement of molecular catalysts in metal-organic frameworks has the potential to lead to significant improvements in selectivity, long term activity and catalyst stability.

Software development is a complex process. It is important that software products become stable and maintainable assets.

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.