With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Mycoheterotrophy is a particular mode of life in which plants obtain carbohydrates from their associated fungal partners, instead of by using photosynthesis.

It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

Biopolymer sequencing with graphene edge-based tunnel junctions has the potential to overcome current limitations with the third generation of sequencing based on biological nanopores.

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

De juiste student op de juiste plek

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

In a typical glycosylation reaction, a donor is activated to form a (variety of) electrophilic species which can react with a nucleophilic acceptor, following a reaction mechanism having both SN1 and SN2 character.

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

Outflows are crucially important for the gas budget and evolution of luminous star-forming galaxies and AGNs, with observed mass outflow rates of the same order as the star formation rate. Greater star formation and black hole growth lead to more intense feedback and outflows, resulting in self-regulated…

Promotor: F. Arbab

This thesis applies data mining in commercial settings in the telecommunications industry.

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

We explored the Universe using weak gravitational lensing, a phenomenon that occurs when light from distant galaxies is bent by the gravitational fields of closer cosmic objects, much like how a lens distorts light.

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

This proposed research uses ego-documents from visual artists that were not intended for publication to reassess the scholarly debate on the demise of the Russian Avant-garde aesthetic in the twenties and early thirties of the 20th century.

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Promotor: B.van de Water, Co-promotor: L.S.Price

Ben jij een nieuwsgierige en enthousiaste student en wil je meer naast je studie doen? Dan is het honoursonderwijs misschien wel iets voor jou.

I have studied the hot, diffuse gas around and between galaxies. Specifically, I have used the EAGLE numerical simulations of galaxy formation to predict the properties of this gas, and I have used those properties to predict specific observables: soft X-ray absorption and emission lines.

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

Animal diet studies are critical for understanding ecological processes such as trophic interactions, energy flow, and nutrient cycling. By examining what animals consume, ecologists gain insights into species specialization, predator-prey relationships, and ecosystem management.

The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.

Ben jij een nieuwsgierige en enthousiaste student en wil je meer naast je studie doen? Dan is het honoursonderwijs misschien wel iets voor jou.

Promotor: J. A. Bouwstra

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Promotor: J. Aarts

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

Interdisciplinaire onderwijs- en onderzoeksprojecten

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

The thesis explores micromammal fossils from the Afşar section in Anatolia, a crucial locality for understanding the Pliocene epoch and the transition to the Villafranchian Age.

This thesis explores how bees and hoverflies are distributed across the Dutch landscape and how ecological and landscape factors shape their occurrence.

This thesis addresses the challenge of sustainable urban development by analyzing the interplay between green and grey infrastructure to optimize resource use and ecosystem services.

Hydrogen-based fuels are regarded as promising candidates for decarbonizing the maritime shipping sector.