Promotores: W. Th. F. den Hollander, M.O. Heydenreich

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

We explored the Universe using weak gravitational lensing, a phenomenon that occurs when light from distant galaxies is bent by the gravitational fields of closer cosmic objects, much like how a lens distorts light.

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

This proposed research uses ego-documents from visual artists that were not intended for publication to reassess the scholarly debate on the demise of the Russian Avant-garde aesthetic in the twenties and early thirties of the 20th century.

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Promotor: B.van de Water, Co-promotor: L.S.Price

Ben jij een nieuwsgierige en enthousiaste student en wil je meer naast je studie doen? Dan is het honoursonderwijs misschien wel iets voor jou.

I have studied the hot, diffuse gas around and between galaxies. Specifically, I have used the EAGLE numerical simulations of galaxy formation to predict the properties of this gas, and I have used those properties to predict specific observables: soft X-ray absorption and emission lines.

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

Animal diet studies are critical for understanding ecological processes such as trophic interactions, energy flow, and nutrient cycling. By examining what animals consume, ecologists gain insights into species specialization, predator-prey relationships, and ecosystem management.

The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.

Ben jij een nieuwsgierige en enthousiaste student en wil je meer naast je studie doen? Dan is het honoursonderwijs misschien wel iets voor jou.

Promotor: J. A. Bouwstra

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Promotor: J. Aarts

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

Interdisciplinaire onderwijs- en onderzoeksprojecten

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

The thesis explores micromammal fossils from the Afşar section in Anatolia, a crucial locality for understanding the Pliocene epoch and the transition to the Villafranchian Age.

This thesis explores how bees and hoverflies are distributed across the Dutch landscape and how ecological and landscape factors shape their occurrence.

This thesis addresses the challenge of sustainable urban development by analyzing the interplay between green and grey infrastructure to optimize resource use and ecosystem services.

Lezing

Veel van onze lezingen zijn opgenomen. Op deze plaats zullen ze beschikbaar zijn. Soms tijdelijk, soms voor langere tijd. De opnames bevatten zowel het beeld van de beeldpresentatie (als die er was) als een beeld van de sprekers.

This thesis investigates Open-world Continual Learning (OWCL), a learning paradigm designed for intelligent systems operating in non-stationary environments with persistent exposure to unknown data.

This thesis investigates innovative and classical strategies in glycoconjugate vaccine development to address the growing threat of multidrug-resistant bacterial infections.

Hydrogen-based fuels are regarded as promising candidates for decarbonizing the maritime shipping sector.

Wij zijn aangesloten bij Una Europa: een alliantie van elf vooraanstaande Europese universiteiten.

Ben jij benieuwd waarom mensen zijn zoals ze zijn – en hoe ze veranderen? Bij de Universiteit Leiden duik je in maatschappelijk gedrag, ideeën en culturen, van vroeger tot nu en van lokaal tot wereldwijd. Van grote steden tot wereldreligies, van filosofische vragen tot opvoeding en onderwijs – je onderzoekt…

Ben jij benieuwd waarom mensen zijn zoals ze zijn – en hoe ze veranderen? Bij de Universiteit Leiden duik je in maatschappelijk gedrag, ideeën en culturen, van vroeger tot nu en van lokaal tot wereldwijd. Van grote steden tot wereldreligies, van filosofische vragen tot opvoeding en onderwijs – je onderzoekt…

This thesis aims to develop model-based approaches to optimize drug dosing in patients with overweight and (morbid) obesity.

Breast cancer (BC) is a clinically and biologically heterogeneous disease.

Anionic particles play an important role in biological systems where they fulfil many essential functions for cells.

Metal-organic compounds hold great promise as photoactivated chemotherapy (PACT) agents, leveraging their unique geometric and electronic properties to achieve precise spatiotemporal control over drug activation.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Workshop

Richard Chancellor, de Engelse Willem Barentsz, ontdekte tijdens de eerste Engelse expeditie de Noordkaap. Maar het schip Edward Bonaventura ‘werd bij terugkomst in 1554 door Vlamingen beroofd’. Historicus Louis Sicking en jurist Remco van Rhee ontdekten de details over deze beroving in Brusselse ar…

Om belangrijke thema’s zoals klimaat en mensenrechten hoger op de agenda van beursgenoteerde bedrijven te krijgen, moeten naast aandeelhouders en werknemers ook andere stakeholders officieel meer inspraakmogelijkheden krijgen. Dat zei hoogleraar Ondernemingsrecht Harold Koster in zijn oratie op 18 maart.…

Eind december vond het afsluitende college plaats van de Bachelor Honours Class ‘Policy and Politics: struggling to combat social inequalities’. In het vak zijn studenten, onder leiding van oud-minister Jet Bussemaker, bezig geweest met de vraag wat ongelijkheid is. “Je kan er niet omheen als je naar…

Nu zowel oude als nieuwe democratieën steeds vaker te maken krijgen met negative ontwikkelingen op democratisch gebied, is er vanuit maatschappelijk oogpunt behoefte om het ontwerp en de effectiviteit van democratische 'checks and balances' te herzien. Het doel van de conferentie op vrijdag 9 juni is…

Congres/symposium

Lezing, Workshop