Promotor: J. Aarts

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

Dissolution processes – next to aggregation processes - play an important role for fate prediction and environmental risk assessment of metal-based nanoparticles (MNPs). It is challenging to predict the kinetics of the dissolution process of MNPs in complex systems such as we can find in in vivo and…

Promotores: P.G.L. Klinkhamer, P.M. Brakefield, Co-Promotor: M. Bruinsma

Promotor: J. Kuiper

In the first part of this thesis we study the geometry of folding patterns.

Supervisor: P.J.J. Hooykaas

In today's volatile market environments, companies must be able to continuously innovate. In this context, innovation does not only refer to the development of new products or business models but often also affects the entire organization, which has to transform its structures, processes, and ways of…

This collection of papers was compiled in celebration of the remarkable academic career of Professor Wil Roebroeks, who has established himself as one of Europe’s leading figures in Palaeolithic archaeology over the past three decades and founded the Human origins research group at Leiden University…

Lezing

The global transition toward low-carbon energy systems and the rapid expansion of digital technologies, including artificial intelligence, are reshaping how modern societies produce, move, and process energy and information.

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

My work focuses on a class of astronomical objects called protoplanetary disks.

Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the highest mortality rate, despite a relatively low incidence.

This thesis investigates catalytic reactions at the atomic scale using scanning tunneling microscopy (STM), with a focus on Fischer–Tropsch synthesis, a key industrial process that converts hydrogen and carbon monoxide into liquid fuels.

Gaucher disease is a rare metabolic disorder, in which a mutation of the enzyme glucocerebrosidase (GBA1) causes buildup of its substrate glucosylceramide and the deacylated counterpart glucosylsphingosine in lysosomes.

This thesis focuses on developing new chemical synthesis strategies to produce native ADP‑ribosylated biomolecules with precise structural control.

Preterm birth is a major contributor to neonatal morbidity and mortality and is associated with both acute complications and long-term health consequences.

Lezing

Promotores: T.H. Oosterkamp, N. de Jonge

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System⁠. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune⁠.

Anionic particles play an important role in biological systems where they fulfil many essential functions for cells.

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

Effective policy-making requires understanding what truly causes a problem. Only then can policymakers develop targeted interventions that achieve desired outcomes.

Traditional biochemical methods for studying organelles require cell disruption, preventing the real-time observation of dynamic intracellular processes.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

Bijna een eeuw na de bejubelde uitspraak van 1928 in de rechtszaak aangaande de ‘Fabriek van Chorzów’, waarin het Permanente Hof van Internationale Justitie het essentiële principe van schadeloosstelling in internationaal recht bevestigde, staat deze ter discussie. De uitspraak is de basis van de claim…

De eerste films werden zo'n 135 jaar geleden gemaakt. Tot in de jaren twintig van de vorige eeuw bestond het geluid bij film uit niet veel meer dan het ratelen van de projector en mu-ziek die ter plekke werd uitgevoerd door één of meer musici. Rond de Eerste Wereldoorlog werd deze muziek steeds vaker…

Herta Mohr was een veelbelovende Egyptoloog die omkwam in Bergen-Belsen. Jurist Amandus Wolfsbergen stierf in Auschwitz, niet wetende dat zijn werk decennialang gezaghebbend zou zijn. Dankzij onderzoek van promovendus Adriënne Baars is de universitaire lijst van ‘Leidse’ oorlogsslachtoffers nu aangevuld…

Als symbool van het kwaad staat de Holocaust in het hart van de westerse herinneringscultuur. Maar die herdenking leidt tot heel uiteenlopende inzichten, stelt Cleveringa-hoogleraar Frank van Vree in zijn oratie. Is de geschiedenis een bron van identiteit of kritische reflectie?

Ieder jaar herdenkt de Universiteit Leiden op 26 november de protestrede van professor Cleveringa tegen de nazi’s. In de Tweede Wereldoorlog kwamen tenminste 663 studenten, medewerkers en alumni van de universiteit om. Over deze slachtoffers was weinig bekend. Promovendus Adriënne Baars achterhaalde…

Dit boek neemt je mee op een 1000-jarige wereldreis aan de hand van 100 bijzondere oude kaarten.

De Surinamer Paul Christiaan Flu was een briljante tropenarts die in 1938 rector magnificus werd van de Universiteit Leiden. De oorlogsjaren maakten echter abrupt een einde aan zijn bliksemcarrière: zijn zoon werd vermoord en zelf zat hij gevangen in een concentratiekamp.

Congres/symposium

Een nieuwe gedenksteen op de gevel van een studentenhuis in de Hugo de Grootstraat herinnert aan de tientallen Indonesische studenten die voor de Tweede Wereldoorlog in Leiden studeerden. Een deel daarvan werd actief in het verzet en sommigen moesten dat met de dood bekopen.

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

Promotor: Prof.dr. M.A.G.J. Orrit

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.