To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Before the large scale use of renewable energy sources can be implemented in our society, the storage of electrical energy needs to be tackled. Storage the energy as hydrogen via the reduction of protons is a good option.

Promotor: G.P. van Wezel

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Kunst en vrije tijd, Kunst en vrije tijd

Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters

Symposium

Promotores: G.R. de Snoo, B. Sinsin, Co-Promotor: H.H. de Iongh

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

LUC-historica Jacqueline Hylkema ontmaskerd vervalsingen uit de vroegmoderne Nederlandse Republiek in het onderzoeksproject 'De Valse Republiek'.

On 15 December 2022, the following thematic report of the European Equality Law Network was published: Christa Tobler, Indirect discrimination under Directives 2000/43 and 2000/78, for the European Commission, Luxembourg: Publications Office of the European Union 2022.

In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.

Radboud University is looking for a PhD researcher who will investigate the afterlife of medieval thought in early modern Europe through the study of concrete instances of intellectual transfer, for instance the appropriation of specific medieval authors or early modern revaluations of specific themes…

In zijn nieuwe boek 'Overstromingen en beheer van grote laaggelegen rivieren' onderzoekt Paul Hudson, universitair hoofddocent fysische geografie bij Leiden University College in Den Haag, de menselijke invloed op rivieren in laagland. De afgelopen twintig jaar is de druk op grote laaggelegen rivieren…

Joris Larik is de nieuwe onderwijsdirecteur bij Leiden University College The Hague (LUC). Het komt op een mooi moment: hij is er precies tien jaar werkzaam. Na veel ervaringen en uitdagingen blikt hij nu vooruit. ‘Hoe blijven we vernieuwen?’

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

De kersverse Amerikaanse president Donald Trump hield op 20 januari zijn inaugurele rede. Zijn toespraak was weinig verzoenend en nam een loopje met de waarheid, menen verschillende Leidse wetenschappers. Een enkele hoogleraar is positiever: 'hij wil de strijd aanbinden met de radicale islam.'

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The conference 'Beyond Comparison: Towards a Connected Philology' is focused on identifying and examining the connections that create or lie behind parallels between philological methods and traditions in various cultures. Deadline for submissions: 30 November 2022.

Dit was het programma van De Kennisboomgaard 2025:

This collection of papers was compiled in celebration of the remarkable academic career of Professor Wil Roebroeks, who has established himself as one of Europe’s leading figures in Palaeolithic archaeology over the past three decades and founded the Human origins research group at Leiden University…

Abstract submission is now open for the international conference of the ELS Academy, in Amsterdam on September 1 and 2. For the 2022 International ELS Conference, we invite all involved in legal research using qualitative and/or quantitative methods to submit abstracts, that may focus on ongoing or…

Abstract submission is now open for the international conference of the ELS Academy, in Amsterdam on September 1 and 2.

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

The majority (80%) of e-waste generated globally are recycled informally in developing countries.

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In this thesis we study products of linear error correcting codes.

Kunst en vrije tijd, Kunst en vrije tijd

Conventional food supplies procured from rural areas are increasingly vulnerable to disruptions caused by extreme weather, geopolitical instability, and logistical bottlenecks.

Leiden University would like to express its concern about the proposed Hungarian higher education draft law, which, if adopted, would make the functioning of Central European University (CEU) in Budapest nearly impossible. These changes would endanger the academic freedom vital for CEU’s continued operation…

The interest of this thesis lies in spin transport in normal metals and superconducting half-metallic junctions.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

Thijs Bosker, Universitair hoofddocent Milieuwetenschappen bij Leiden University College (LUC) en het Centrum voor Milieuwetenschappen (CML), heeft samen met 19 andere partijen een subsidie van in totaal 7 miljoen euro ontvangen voor het project PAPILLIONS. Hoofdaanvrager is het NIVA, het Noorse RIVM.…

Als psycholoog én piloot is Bert Busscher geïnteresseerd in het fenomeen vliegangst. Busscher ontdekte dat aan de hartslag van mensen tijdens een therapeutische vlucht is af te lezen hoeveel last zij nog van hun vliegangst hebben. De hartslag na de vlucht voorspelt zelfs of de vliegangst op lange termijn…

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

In 2067 allemaal online naar de psycholoog? Een stoomcursus tijdreizen of juist terug in de tijd met Vincent van Gogh langs de hallucineermeetlat? Onder psychologen zijn Winnie Gebhardt, Andrea Evers en Jan Dirk Blom van de partij in de Nacht van Kunst & Kennis.

In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

Understanding interactions in quantum many-body systems remains one of the most profound and difficult challenges in condensed matter physics.

Ice, the solid state of water, plays an important role on our planet as well as the entire universe.Despite the fact that an individual water molecule has a very simple structure, its chemical bonding in the solid phase can be surprisingly complex.

Bekijk de toelatingseisen voor MSc International Organisation aan Universiteit Leiden in Den Haag. Inclusief benodigde 80 ECTS, Engelse taalnormen (IELTS/TOEFL) en ondersteunende documenten.

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