In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

The endophytic microbiota is a community of various microorganisms that reside in plant tissue. These microbes are known to promote plant health and resilience, and their members do not simply exist side by side.

The rapid expansion of research on human gut microbiome in recent decades has highlighted its role in human metabolism, immune regulation, and behavior.

Toll-like receptors (TLRs) are central components of the innate immune system, functioning as pattern recognition receptors that detect microbial- and damage-associated molecular patterns and initiate antimicrobial and inflammatory responses.

This thesis was embedded in the APELAFICO project and focussed on investigating effects of sound from North Sea offshore wind farms on pelagic fish and harbour porpoise.

All the data stored and processed by our computers is encoded as sequences of zeros and ones, called bits. Quantum computers offer an alternative to this traditional way of encoding and manipulating information.

Wat als ernstig zieke patiënten hun diagnose niet willen horen? Moet een arts een patiënt altijd alle beschikbare informatie geven? Communicatieonderzoeker Liesbeth van Vliet, medisch antropoloog Annemarie Samuels en onderzoeksstagiaire Fiona Brosig stelle deze vragen over open informatievoorziening…

Sinds de oprichting is LUC een college voor onderwijsontwikkeling en experimentatie. In de missie van het college wordt LUC beschreven als "een plek van innovatie op het gebied van didactiek, curriculumontwerp en studentwelzijn." Deze visie wordt toegepast via een studentgerichte benadering in het onderwijs…

This thesis focuses on the study of transient and variable radio sources in the universe.

This thesis probes under what conditions quantum computing presents an advantage over classical computing.

We show that Kirchhoff ’s law of conservation holds for non-commutative graph flows if and only if the graph is planar. We generalize the theory of (Euclidean) lattices to infinite dimension and consider the ring of algebraic integers as such a lattice.

Promotor: Prof.dr. C.U. Keller, Co-promotor: Frans Snik

M.T.M. Koper, Co-promotor: D.G.H. Hetterscheid

Statistical distributions in LCA and converting between different representations of these distributions.

This thesis consists of three chapters. Each chapter is on a different subject. However, all three chapters address issues that arise in counting arithmetically interesting objects.

With the rise of multi-drug resistant bacterial pathogens, the possibility of a post-antibiotic world is quickly becoming reality.

This thesis consists of two subjects, that are both a consequence of radiation pressure.

Promotores: Prof.dr. D. Bouwmeester, Prof.dr. A. Fiore (TU Eindhoven)

Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal

This thesis investigates how non-genetic factors, such as inflammation and concomitant medication, impact hepatic drug metabolism and subsequent drug metabolizing phenotype predictions.

Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

This thesis examines silicon pore optics (SPO), a technology that exploits silicon wafers from the semiconductor industry to create extremely high quality X-ray optics, by studying its manufacturing process, applications, and prospects.

The experiences of ethnic ‘Other’ females have – until recently – been widely overlooked in the study of sport. There continues to be a need to produce critical scholarship about ethnic 'Other' girls and women in sport and physical culture, in order to represent their complex, multifarious and dynamic…

Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf

This thesis investigates the structural evolution and assembly of galaxies since the first few billions years after the big bang.

A Josephson junction is a device where a thin insulating barrier or a nanostructure is placed between two superconducting leads. Such a junction is essential to superconducting qubits that store quantum information due to its anharmonic spectrum.

The formation of stars and planets happens over multiple scales, which can interact. In particular, planet formation happens in the dense, complex environment of star forming regions.

Extending our current arsenal of antibiotics is key to staying ahead in the arms race between humans and resistant bacteria.

Make more fluid: In condensed matter systems, electrons can acquire unusual properties from their interaction with the atomic lattice.

This thesis is an experimental study of the UV irradiation of the interstellar ice analogues, relevant for the different stages of the star and planet formation sequence.

In unconventional high temperature superconductors, supercurrent vortices are known to spoil the Landau levels. In this thesis the emergence of Landau levels is studied in different types of superconductors: Weyl superconductors, and the Fu-Kane heterostructure.

Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.

Wat maakte het vroege islamitische rijk zo succesvol en hebben we het verhaal gemist door cruciaal bewijs te negeren? De Arabische veroveringen in de 7e eeuw veranderden de sociaal-politieke configuraties in het Middellandse Zeegebied en Eurazië voorgoed. Toch weten we niet echt hoe de Arabieren erin…

This Thesis shows discoveries in non-linear astrochemical kinetics as well as a deeper analysis of dark clouds chemistry.

The impact of the phenotypic plasticity of P. aeruginosa and the distinct CF lung microenvironments on antibiotic drug effects and resistance remains poorly understood.

Social event

Grensverleggend geschiedenis leren.

Afgestudeerden van de bachelor Security Studies aan de Universiteit Leiden hebben toegang tot diverse masterprogramma's en uitstekende carrièrekansen. Ontwikkel je als beveiligingsstrateeg en vergroot je kansen op een succesvolle carrière in zowel de publieke als private sector.

We verwelkomen gastwetenschappers wier onderzoek aansluit bij onze uiteenlopende expertisegebieden. De tekst gaat verder in het Engels.

Webinar with Q&A

Congres/symposium, Workshop

Prof. dr. Bernhard Hommel heeft een Advanced Grant ontvangen van de European Research Council (ERC). Met deze beurs van 2,5 miljoen euro gaat de cognitief psycholoog vijf jaar lang onderzoek doen naar 'metacontrole'; de manier waarop wij bepalen hoe groot de invloed van onze doelen is op ons daadwerkelijke…

Drie Leidse wetenschappers ontvangen een ERC Advanced Grant. Daarmee doen zij de komende vijf jaar onderzoek naar exoplaneten, de vrije wil en deeltjesfysica.