The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

Including modelling as part of software development appears to have various benefits.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Gibbs measures, as used in Statistical Mechanics, have a definition that is remarkably similar to the definition ofg-measures, used in dynamical systems.

Promotor: Prof.dr. D. Bouwmeester

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

Promotor: Prof.dr. E Gittenberger, Co-Promotores: C.H.J.M. Fransen, B.W. Hoeksema

The invention of neural networks marks a critical milestone in the pursuit of true artificial intelligence. Despite their impressive performance on various tasks, these networks face limitations in learning efficiently as they are often trained from scratch.

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. H. Leirs (Univ. Antwerpen)

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

This thesis studied in depth the energy use and CO2 emissions of the industrial sector in China.

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

Promotor: J.S. Kaastra Co-promotor: E. Constantini

Consequences for sediment stability and seston trapping

Hydrocarbonylation of alkenes with carboxylic acids in synthesis of carboxylic acid anhydrides is relatively less explored. We herein present a study and optimization of a palladium-catalyzed hydrocarbonylation reaction of alkenes using carboxylic acids as the nucleophile, by which acid anhydrides can…

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Nowadays, it is well known that hydrogen and helium (and small traces of lithium and beryllium) were created shortly after the Big Bang, while the heavier elements are created in the cores of stars at different evolutionary stages. When these stars explode as supernovae, they expel metals synthesised…

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The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.

Promotor: I. A. G. Snellen, Co-promotor: M. A. Kenworthy

De onderzoeksgroep Governance of Crises bestudeert fenomenen, dynamieken en actoren die te maken hebben met crisisgovernance. Het Crisis Research Center (CRC) van de Universiteit Leiden maakt deel uit van deze onderzoeksgroep.

The name ‘Jambi flora’ refers to fossil plants found as part of a rock formation from the Early Permian (296 million years old), located in the Jambi Province of Sumatra, Indonesia.

Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Promotor: Prof.dr. T. Schmidt

Promotores: J. Jonkers, K.E. de Visser

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Women Writing Mexico (WWM) is a network of women and men concerned with the human rights crisis in Mexico and more specifically, with the impact of structural forms of poverty, everyday violence, and discrimination based on gender, race, social class, and ethnicity, that particularly have an impact…

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

In this thesis we investigate cosmology and the large scale structure of the Universe using cosmological simulations.

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

Promotores: K.J. Batenburg, B. Koren

The aromatic infrared bands (AIBs) seen throughout the interstellar medium (ISM) are generally thought to be carried by polycyclic aromatic hydrocarbons (PAHs) and their nitrogen analogues (PANHs).

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma