Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

Promotor: H.V.J. Linnartz

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Promotor: A.P. IJzerman

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

This dissertation, Layered Loyalties: The Natuurkundige Commissie in the Netherlands Indies (1820-1850), studies the Natuurkundige Commissie.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.

Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

To meet the rising demand for minerals driven by the global shift to clean energy technologies, ensuring responsible and resilient supply chains is critical. Minerals like cobalt, lithium, and nickel for batteries, neodymium and zinc for wind turbines, and indium for solar panels are essential.

Animal diet studies are critical for understanding ecological processes such as trophic interactions, energy flow, and nutrient cycling. By examining what animals consume, ecologists gain insights into species specialization, predator-prey relationships, and ecosystem management.

A key step in the synthesis of oligosaccharides and glycoconjugates is the formation of the glycosidic bond.

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.

Promotor: H.W. Lenstra

Het onderwijsprogramma van Clinical Psychology is gericht op het verkrijgen van gespecialiseerde kennis van psychopathologie, diagnostische- en behandelvaardigheden en daaraan gerelateerd wetenschappelijk onderzoek.

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Promotor: J. Aarts

In this thesis integral points on affine del Pezzo surfaces are studied.

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Op 13 januari 2022 verdedigde Pie Habimana het proefschrift 'Harmful Tax Competition in the East African Community'. Het promotieonderzoek is begeleid door prof.dr. H. Vording en prof.dr. S.C.W. Douma (UvA).

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

Dissolution processes – next to aggregation processes - play an important role for fate prediction and environmental risk assessment of metal-based nanoparticles (MNPs). It is challenging to predict the kinetics of the dissolution process of MNPs in complex systems such as we can find in in vivo and…

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

In today's volatile market environments, companies must be able to continuously innovate. In this context, innovation does not only refer to the development of new products or business models but often also affects the entire organization, which has to transform its structures, processes, and ways of…

The thesis explores micromammal fossils from the Afşar section in Anatolia, a crucial locality for understanding the Pliocene epoch and the transition to the Villafranchian Age.

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

This thesis addresses the challenge of sustainable urban development by analyzing the interplay between green and grey infrastructure to optimize resource use and ecosystem services.

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

In populations with a seed-bank, individuals can temporarily become dormant and refrain from reproduction until they can become active again. The repository of all dormant individuals in the population is called the seed-bank. Seed-banks are observed in many taxa, including plants, bacteria and other…

De Universiteit Leiden en het Roosevelt Institute for American Studies (RIAS) in Middelburg, voorheen het Roosevelt Study Center, ondertekenen op 16 december 2016 een overeenkomst over strategische samenwerking.

For questions and suggestions regarding the series, please contact prof. dr. Olaf van Vliet or dr. Max van Lent

De Young Academy Leiden verwelkomt maandag 20 september 6 nieuwe leden waaronder pedagoog Rachel Plak. Vanmiddag vindt er een de dubbele inauguratieceremonie plaats van deze leden én de leden die zich afgelopen jaar hebben aangesloten bij YAL. De ceremonie is van 17.00 uur tot 18.00 uur in het Academiegebouw…

In het kader van een samenwerkingsovereenkomst met de Nationale Politie werd aan de onderzoeksgroep Intelligence and Security een team Politiestudies toegevoegd. Dit team heeft tot doel om de huidige kennis rond politiestudies in Nederland te verwetenschappelijken, te verbreden en te verdiepen. Wetenschappelijke…

This Panel at the Historians of Netherlandish Art Conference (Amsterdam, 2-5 June 2021) aims to explore how early modern individuals and groups branded themselves through their heraldic presentation on contemporary social media and materials. Although this call for papers focuses on the period 1500-1800,…

Wetenschappers moeten gemakkelijker gebruik kunnen maken van elkaars data, vindt een groep onderzoekers van verschillende universiteiten. Daarvoor ontwikkelden ze de FAIR-principes. BNR Nieuwsradio sprak erover met initiatiefnemer Barend Mons, hoogleraar Biosemantiek aan het Leids Universitair Medisch…

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The logic seems inescapable indeed. The bigger the population, the higher the probability it contains an Einstein. Hence, bigger populations are more likely to develop complex culture.

Het Leids Universitair Centrum voor de studie van Islam en Samenleving (LUCIS) en de Abdulaziz Saud Al-Babtain Cultural Foundation gaan samenwerken om de bestudering van Arabische cultuur te versterken. Met financiële steun van Abdulaziz Saud Al-Babtain zal LUCIS in 2018 en 2019 een gerenommeerde gasthoogleraar…