Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

This thesis consists of five chapters on how to construct prediction sets for different types of data and models in a parametric or nonparametric Bayesian paradigm.

The LUGO Press is a student publication forum, rooted in academia and journalistic practices and published by the Leiden University Green Office.

Around the world, mindfulness has become big business. This course combines conventional scholarly inquiry from multiple disciplines with experiential learning to provide a responsible, comprehensive, and inclusive education about mindfulness as a contemporary phenomenon.

Deze opleiding biedt de mogelijkheid om onderzoek op moleculair, cellulair en organismaal niveau te verenigen, maar biedt ook de mogelijkheid om je te specialiseren op één van deze niveaus.

Explore "Statistical Aspects of Clinical Trials" at Boerhaave Nascholing. Dive into trial design, analysis, and practical sessions. Read more here.

Explore "Statistical Aspects of Clinical Trials" at Boerhaave Nascholing. Dive into trial design, analysis, and practical sessions. Read more here.

A series of workshops at Leiden University and the University of Hamburg will act as a forum in which international legal scholars whose research adopts a behavioural approach can present their works-in-progress and gain feedback from a broad range of peers, including scholars in economics and cognitive…

Since 2013, Leiden University has offered MOOCs in cooperation with Coursera. Over 80,000 students have enrolled in our MOOCs on European Law (Prof. dr Stefaan van den Bogaert) and on Terrorism & Counterterrorism (Prof. dr. Edwin Bakker).

Due to the COVID19 crisis (especially the impossibility to meet in person), the course "Foundations of Research-2" could not take place as scheduled. However, a second opportunity to participate in this course in October will be offered. The course is aimed at PhD students who are about halfway…

Een onderzoek naar hoe mensen eten en drinken tijdens hun dagelijkse routines, en onder welke omstandigheden dit plaatsvindt.

Promotores: R. Tijdeman, K.J. Batenburg

Risk has become one of the defining features of modern society. This course examines various types of safety and security risks, and how these are perceived and dealt with in a wide array of professional and academic fields, ranging from criminology, counter-terrorism and cyber security, to philosophy,…

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.

Lezing

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.

Understanding DNA repair mechanisms is essential for advancing plant biotechnology and crop improvement. This study investigates how double-strand breaks (DSBs), induced by CRISPR/Cas systems, are repaired in the model plant Arabidopsis thaliana, and how these processes influence Agrobacterium tumefaciens…

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

Promotor: M.T.M. Koper, Co-promotor: L. Juurlink

Promotor: S.M. Verduyn Lunel

Promotor: G.P. van Wezel

Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.

This work is dedicated to interpreting in cohomological terms the special values of zeta functions of arithmetic schemes.

Promotor: A. Achúcarro Co-promotor: A. Boyarsky

Promotor: Prof.dr. E. Eliel, Co-Promotor: M.J.A. de Dood

This thesis manuscript explores the use of video games as tools for conceptual exploration and academic research.

Global Environmental Extensions Multi-Regional Input-Output (EE-MRIO) analysis is often used to analyze how changes in global and national demand for products lead to socioeconomic and environmental impacts at the national level.

Organic amendments applied to agricultural fields can partially offset our carbon emissions to the atmosphere and improve the resilience of agriculture to the effects of climate change. Driving these benefits, however, are complex and poorly understood interactions between organic amendment properties,…

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

This thesis investigates how cell shape and collective behavior influence the dynamics and structure of biological tissues, which are crucial for understanding processes like embryonic development, tissue regeneration, and metastasis.

Publicaties van het Leids Papyrologisch Instituut

This thesis is a collection of theoretical works aiming at adjusting quantum algorithms to the hardware of quantum computers.

In this work, I explore the creation of new methods that optimize simulations of the gravitational N-body problem. Specifically, I take advantage of the recent popularity of Machine Learning methods to find tools that can suit this problem.

This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids.

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

SDN (Software-Defined Networking) represents a revolutionary approach to network architecture that enables the dynamic and flexible management of network resources through software-based control. This dissertation introduces the idea of SDN and its southbound protocol OpenFlow, then presents the formal…

With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.