Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Catharanthus roseus (Madagascar periwinkle) produces valuable monoterpenoid indole alkaloids (MIAs) such as vincristine and vinblastine, crucial for cancer treatment.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Prostate cancer (PCa) is one of the most prevalent cancer in males.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Promotores: G.W. Canters, T.J. Aartsma

This thesis investigates opinion dynamics on random graphs through the lens of the voter model, a classical interacting particle system used to describe how consensus emerges in networks.

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

In this thesis, we study different curved single crystals because of the diversity of surface structures across their curvature.

Sorghum (Sorghum bicolor) is a major cereal crop that millions of subsistence farmers in Sub-Saharan Africa (SSA) rely on. However, the scourging impact of the root parasitic weed Striga (Striga hermonthica, a.k.a. “witch-weed”) has remained a major constraint hampering the productivity of sorghum in…

Promotor: E.F. Smets, Co-promotor: T.R. van Andel

Klinische psychologie richt zich vooral op de toepassing van wetenschappelijke psychologische kennis op assessment, preventie en behandeling van psychopathologie.

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Understanding interactions in quantum many-body systems remains one of the most profound and difficult challenges in condensed matter physics.

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.

In this thesis we study bistable reaction-diffusion equations on lattice domains.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Promotor: Prof.dr. A. Doelman, Co-promotor: V. Rottschäfer

Hospital pharmacies face significant challenges: the demand for sterile drug reconstitutions is increasing, while specialized personnel remain scarce. Automation offers a potential solution, but its practical implementation in hospitals is still unclear.

The AT-Hook Nuclear Localized 15 (AHL15) gene belongs to a plant-specific gene family of DNA-binding proteins. Overexpression of AHL15 in Arabidopsis thaliana delays developmental phase transitions whereas its loss of function causes a slight acceleration.

Het gebruik van ‘Big data’ is niet meer weg te denken binnen het wetenschappelijk onderzoek. Voor dit onderzoek maken we gebruiken van diverse grote databestanden.

Promotor: J. Zaanen

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli

Promotor: Prof.dr. M.L. van Hecke

Van oudsher werden donder en bliksem gezien als Gods strafwerktuigen. De uitvinding van de bliksemafleider door Benjamin Franklin in 1752 bracht hierin echter verandering. Welke gevolgen hadden de uitvinding en invoering van de bliksemafleider voor de manier waarop men aankeek tegen het onweer? Jan…

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.

This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

Control of infectious diseases poses continuous challenges for human health.

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra

This thesis mainly extends the theory of positive operators on Riesz spaces to a setting of pre-Riesz spaces.

Promotor: Prof.dr. P.G.L. Klinkhamer, Co-Promotor: T.J. de Jong

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.

Promotor: C.J. ten Cate

Following the Big Bang, structure in the Universe started collapsing under the force of gravity. This resulted in the formation of the first stars, galaxies and clusters of galaxies.

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

Promotor: J.S. Kaastra Co-promotor: E. Constantini

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra