The AT-Hook Nuclear Localized 15 (AHL15) gene belongs to a plant-specific gene family of DNA-binding proteins. Overexpression of AHL15 in Arabidopsis thaliana delays developmental phase transitions whereas its loss of function causes a slight acceleration.

Het gebruik van ‘Big data’ is niet meer weg te denken binnen het wetenschappelijk onderzoek. Voor dit onderzoek maken we gebruiken van diverse grote databestanden.

Promotor: J. Zaanen

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli

Promotor: Prof.dr. M.L. van Hecke

Van oudsher werden donder en bliksem gezien als Gods strafwerktuigen. De uitvinding van de bliksemafleider door Benjamin Franklin in 1752 bracht hierin echter verandering. Welke gevolgen hadden de uitvinding en invoering van de bliksemafleider voor de manier waarop men aankeek tegen het onweer? Jan…

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.

This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

Control of infectious diseases poses continuous challenges for human health.

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra

This thesis mainly extends the theory of positive operators on Riesz spaces to a setting of pre-Riesz spaces.

Promotor: Prof.dr. P.G.L. Klinkhamer, Co-Promotor: T.J. de Jong

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.

Promotor: C.J. ten Cate

Following the Big Bang, structure in the Universe started collapsing under the force of gravity. This resulted in the formation of the first stars, galaxies and clusters of galaxies.

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

Promotor: J.S. Kaastra Co-promotor: E. Constantini

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

Consequences for sediment stability and seston trapping

Promotor: M.K. Richardson, Co-Promotor: F. Witte

Hydrocarbonylation of alkenes with carboxylic acids in synthesis of carboxylic acid anhydrides is relatively less explored. We herein present a study and optimization of a palladium-catalyzed hydrocarbonylation reaction of alkenes using carboxylic acids as the nucleophile, by which acid anhydrides can…

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

We present an extensive study of methods for exactly solving stochastic constraint (optimisation) problems (SCPs) in network analysis. These problems are prevalent in science, governance and industry.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

One of the most important puzzles in modern astrophysics is the nature of dark matter.

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

Tracing the evolution of the molecular gas content in galaxies is critical for a complete understanding of galaxy formation and evolution, as it provides the direct fuel for star formation. Studies of high-redshift (z>1) molecular gas reservoirs, most commonly traced by carbon monoxide (CO), have seen…

EuDEco (modellering van de Europese Data Economie) is een Coordination & Support Action (CSA) die financiering ontvangt van het Europese Horizon 2020 programma.

The applications of studying the early development of insects range from agriculture to material science.

It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Promotor: J. Zaanen, Co-Promotor: V. Juricic

Promotor: W. T. F. den Hollander, F. H. J. Redig

This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

This PhD thesis concerns the topic of arithmetic geometry. We address three different questions and each of the questions in some way is about counting how big some set is or can be.

Large carnivore population is globally declining as a result of the fragmentation of habitat, large prey depletion and retaliatory killing by pastoralists.

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.

We consider the propagation of electrical signals through nerve fibres.

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.