Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

Promotores: J. Jonkers, K.E. de Visser

To an algebraic curve C over the complex numbers one can associate a non-negative integer g, the genus, as a measure of its complexity.

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

Promotor: Jelle S. Kaastra Co-promotor: Jelle de Plaa

To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Tomography is a powerful technique to non-destructively determine the interior structure of an object.Usually, a series of projection images (e.g.\ X-ray images) is acquired from a range of different positions.

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

This thesis investigates the contribution of quantum computers to machine learning, a field called Quantum Machine Learning. Quantum Machine Learning promises innovative perspectives and methods for solving complex problems in machine learning, leveraging the unique capabilities of quantum computers…

Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…

Sound is everywhere in the marine environment and hearing is therefore a very important for stimuli for fish. They use sound for orientation and communication, during migration, aggregation and spawning, but also for detection of prey and predators.

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. H. Leirs (Univ. Antwerpen)

This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…

Promotor: Prof.dr. E Gittenberger, Co-Promotores: C.H.J.M. Fransen, B.W. Hoeksema

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

Combinatorial games are games for two competing players, moving in a turn-by-turn fashion, in which there is no chance nor hidden information⁠. Chess, checkers and the simpler tic tac toe are well-known examples of this class of games, as well as game of go⁠.

Promotores: G.W. Canters, T.J. Aartsma

The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.

Including modelling as part of software development appears to have various benefits.

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

Gibbs measures, as used in Statistical Mechanics, have a definition that is remarkably similar to the definition ofg-measures, used in dynamical systems.

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

Promotor: Prof.dr. D. Bouwmeester

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Image segmentation is a fundamental task in computer vision, with applications ranging from medical diagnostics to archaeological research.

The aromatic infrared bands (AIBs) seen throughout the interstellar medium (ISM) are generally thought to be carried by polycyclic aromatic hydrocarbons (PAHs) and their nitrogen analogues (PANHs).

Een ware prijzenregen voor studenten van de Faculteit Wiskunde en Natuurwetenschappen tijdens de jaarlijkse uitreikingsmiddag van de KHMW-Jong Talentprijzen. Op maandag 25 november ontvingen maar liefst negen eerstejaars een prijs voor beste studieresultaten in het eerste studiejaar. Daarnaast waren…

Vijf Leidse propedeusestudenten hebben een aanmoedigingsprijs van 500 euro ontvangen van de Koninklijke Hollandsche Maatschappij der Wetenschappen (KHMW). Zij haalden het hoogste cijfergemiddelde van hun jaar, in hun studierichting aan de Universiteit Leiden. De Leidse Sebastiaan Haffert heeft daarnaast…

De Olympische medaille van Boudewijn Röell, een antieke skiff en foto’s van roemruchte rituelen. Asopos de Vliet - ook de roeiclub van prinses Beatrix - viert haar 55e jaar met een lustrumexpositie in de Oude UB. Te zien van 1 november t/m 26 januari.

For questions and suggestions regarding the series, please contact prof. dr. Olaf van Vliet or dr. Max van Lent

The basic program comprises a total of twelve courses organized by the Research School, that have been purpose-developed for training and support of PhD students and Research MA students who specialize in Medieval Studies (history, art history, and literary history, in particular).

Antibiotica, bacteriën en resistentie zijn zeer geschikte onderwerpen voor een profielwerkstuk. Hier vind je alvast een aantal handige links.

Emoties en de psychosociale ontwikkeling van kinderen met en zonder Taal Ontwikkelingsstoornis

Naar aanleiding van de cursus ‘Jews, Christians and Mithraists: Urban Traces and Traditions of three “Oriental” Religions in Imperial Rome’ die Jürgen Zangenberg en Renske Janssen gaven aan het Koninklijk Nederlands Instituut in Rome (KNIR), spreken zij in hun eerste zomerspecial aflevering over wat…

Dubbelspoor. De postuum verschenen herinneringen van professor Cees Fasseur (1938 - 2016).

Kies Neerlandistiek aan de Universiteit Leiden:

Van oorlogsmisdaden tot ontheemding. Historicus Gert Oostindie beschrijft in zijn nieuwe boek de dekolonisatieoorlog door de ogen van de Nederlandse militaire die in Indonesië vochten.

Was de progressieve koloniale bestuursambtenaar de voorloper van de post-koloniale ontwikkelingswerker?

Vakdidactiek bedrijfseconomie, ondernemerschap en financiële zelfredzaamheid

Maar liefst twaalf studenten van de Universiteit Leiden hebben een Jong Talent Prijs ontvangen van de Koninklijke Hollandsche Maatschappij der Wetenschappen in Haarlem, een record. Tijdens de feestelijke ceremonie op 25 november kregen vijf masterstudenten een Jong Talent Afstudeerprijs voor hun scriptie…