This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.

Promotor: H.W. Lenstra

Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

Promotor: Prof.dr. E. Smets, M. Stech

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

Promotor: Prof.dr. H.J.A. Rottgering

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

Promotor: Bas Edixhoven, Promotor: Qing Liu

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Lezing

Lezing

Lezing

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

The vegetative growth period for leafy vegetables like lettuce is essential for yield and quality.

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

Lezing, Museum meets University

Door de vergrijzing neemt de druk op de ouderenzorg toe. Hoe zorgen we ervoor dat ouderen gezond en vitaal kunnen blijven leven? In het vak ‘Living Lab’ van de Master Vitality and Ageing (V&A) van het Leids Universitair Medisch Centrum (LUMC) werken studenten aan actuele vraagstukken rond de gezondheid…

Firearms and violence in Europe–A systematic review by Katharina Krüsselmann, Pauline Aarten, Marieke Liem

Prof dr. C.A. van Eck heeft de Descartes-Huygensprijs gekregen. Deze wordt eens in de drie jaar door de Franse Académie des Sciences en de KNAW toegekend aan een geesteswetenschapper. De prijs is gesponsord door de Franse Ambassade in Nederland en wordt toegekend aan Franse en Nederlandse onderzoekers…

Anne van Rongen heeft tijdens de jaarlijkse bijeenkomst van het American College of Clinical Pharmacology (ACCP) in 2024 de Wayne A. Colburn Memorial Award in de wacht gesleept. Deze prijs wordt uitgereikt aan de beste posterpresentatie en is een mooie erkenning voor haar uitstekende onderzoek en pr…

De afdeling bereikte het droevige bericht dat hoogleraar burgerlijk recht prof. mr. A.R. Bloembergen op 1 november 2016 is overleden. Hij wordt met eerbied en dankbaarheid herdacht. Bloembergen was hoogleraar in Leiden van 1965 tot 1979.

This new Casebook features the work of an international, interdisciplinary research group entitled ‘The Joust as Performance: Pas d’armes and Late Medieval Chivalry’.

Sinds 2009 behaalden 95 kandidaten hun doctoraat in Creative en Performing Arts. Op deze pagina een overzicht van ACPA's alumni.

Je studie zit erop: je bent afgestudeerd filosoof. En nu? De mogelijkheden liggen open! Veel afgestudeerden Filosofie gaan aan de slag in rollen waar bijvoorbeeld advisering, onderzoek, lesgeven, voorlichting en communicatie of coördinatie van werk centraal staan. Wat past bij jou? Je mogelijkheden…

Een diversere groep studenten kun je je bijna niet voorstellen. India, Duitsland, Pakistan, Nederland, Israël, Rusland, Italië en Mongolië, allemaal voorbeelden van landen die dit voorjaar vertegenwoordigd zijn in de pilot van het International Leiden Leadership Programme.

The coursework within the Science Communication and Society (SCS) specialisation prepares students for internships and a career in communication about science and health.

Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Op deze pagina vindt u de opnames van de online This Week's Discoveries vanaf 12 mei 2020 en een lijst sprekers vanaf oktober 2015.

Artin L-functions associated to continuous representations of the absolute Galois group G_K of a global field K capture a lot of information about G_K as well as arithmetic properties of K.

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

This thesis investigates how galaxies form and what diversifies the evolutionary histories of galaxies.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Op 12 januari 2022 verdedigde Mirjam Franke het proefschrift 'Over de grens van de onrechtmatige daad'. Het promotieonderzoek is begeleid door prof.mr. A.G. Castermans en prof.mr. J.H. Crijns.

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher