There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Promotores: Prof.dr. M.K. Richardson, Prof.dr. H.P. Spaink. Co-promotor: C.P. Bagowski

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

To meet the rising demand for minerals driven by the global shift to clean energy technologies, ensuring responsible and resilient supply chains is critical. Minerals like cobalt, lithium, and nickel for batteries, neodymium and zinc for wind turbines, and indium for solar panels are essential.

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Gaucher disease is a rare metabolic disorder, in which a mutation of the enzyme glucocerebrosidase (GBA1) causes buildup of its substrate glucosylceramide and the deacylated counterpart glucosylsphingosine in lysosomes.

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Het onderzoek van de sectie Sociale, Economische en Organisatiepsychologie is gericht op het ontwikkelen van modellen om beïnvloeding in sociale systemen te beschrijven en te verklaren. Dit wordt onderzocht binnen het domein Sociale en Organisatiepsychologie, en ook binnen de Economische en Consumen…

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.

Promotor: A. Achúcarro, Co-Promotor: J.W. van Holten

The mission of our group is understanding how science communication works to improve the interaction between science and society. We believe better science communication can improve our society and engage many different groups with science, also improving science.

Op deze pagina vindt u de opnames van de online This Week's Discoveries vanaf 12 mei 2020 en een lijst sprekers vanaf oktober 2015.

Promotor: M.A.G.J. Orrit

It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.

Het onderzoek binnen de Faculteit der Wiskunde en Natuurwetenschappen omvat de disciplines wiskunde, informatica, sterrenkunde, natuurkunde, scheikunde, bio-farmaceutische wetenschappen, biologie en milieuwetenschappen.

Leidse natuurkundigen hebben een manier ontwikkeld om na te gaan hoe nauwkeurig een superconducting single photon detector kan worden onderzocht.

Hulp bij je profielwerkstuk en nog veel meer activiteiten om kennis te maken met Sterrenkunde aan de universiteit!

Natuurkundige Remko Fermin van de Universiteit Leiden heeft een Rubiconbeurs van NWO gewonnen. Daarmee gaat hij onderzoek doen naar supergeleidende diodes die zouden kunnen bijdragen aan het verminderen van de CO2 uitstoot van datacenters.

Leidse wetenschappers en bedrijven ontvangen 1,37 miljoen euro om technologie voor de Einsteintelescoop te ontwikkelen. Deze ondergrondse telescoop gaat zwaartekrachtgolven meten en moet dus extreem gevoelig zijn. Het consortium doet daarom onderzoek naar het dempen van trillingen bij temperaturen rond…

Op 21 november geeft theoretisch natuurkundige Juan Maldacena het Ehrenfest Colloquium. Maldacena is wereldwijd bekend als uitvinder van de AdS/CFT-correspondentie, die een mogelijke sleutel vormt tot een theorie van quantumzwaartekracht. Maldacena is winnaar van de prestigieuze Diracprijs en de Breakthrough…

Kunst en cultuur, Pianoconcert

Nature, nurture and neural mechanisms of social emotion regulation in childhood

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Ongelijkheid beter begrijpen ten behoeve van een eerlijkere, rechtvaardigere samenleving.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

Op 7 februari 2019 verdedigde Helena Ursic-Vrabec haar proefschrift 'Uncontrollable: Data subject rights and the data- driven economy'. Het promotieonderzoek is begeleid door promotor prof. dr. S. van der Hof.

Promotor: Prof.dr. H.S. Overkleeft

In het academisch jaar 2023-2024 biedt het interdisciplinaire onderzoeksprogramma Sociale Veerkracht en Veiligheid vier vakken aan voor studenten die beginnen met het derde jaar van hun bachelor. Deze vakken zijn te volgen binnen de ruimte voor keuzevakken. Je kunt de vakken afzonderlijk als keuzevak…

Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.