This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Promotor: Prof.dr. P. Stevenhagen, Prof.dr. K. Belabas (Univ. de Bordeaux)

In this thesis, we study systems of electrons in which strong correlations give rise to emergent exotic physics.

This thesis revolves around the electronic spectroscopy of molecules in the laboratory and the search for the carriers of the diffuse interstellar bands (DIBs).

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

Promotor: A. Achúcarro Co-promotor: A. Boyarsky

The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Promotor: Prof.dr. M.L. van Hecke

EnSMiRT wil de expertise binnen de alliantie Una Europa benutten en de samenwerking tussen toonaangevende onderzoekers die in verschillende stadia van de minerale waardeketen werken, stimuleren om deze dringende uitdagingen rechtstreeks aan te pakken.

This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

One of the most important puzzles in modern astrophysics is the nature of dark matter.

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

At the largest scales, two ingredients dictate the distribution of matter in the Universe. The first is dark matter, acting as an invisible scaffolding held together by gravitational forces.

Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich

Bicarbonate buffer is largely found in nature due to its ability to regulate pH variations around neutral values. As the pH changes, so does the speciation of the buffer.

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

Hoe leidt zelfredzaamheid tot een afname in samenwerking voor publieke goederen?

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

In this thesis, the role of plant-mediated soil legacy effects in shaping aboveground plant-insect interactions was investigated.

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

The unit residue group, to which the present thesis is devoted, is defined using the norm-residue symbol, which Hilbert introduced into algebraic number theory in 1897.

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Innovation plays an essential role in firms' competitiveness and long-term success. It varies from different types, ranging from run-of-the-mill innovation that brings incremental changes to existing technologies to radical innovation that breaks from existing trajectories.

In this work, we illustrate unconventional approaches towards the fabrication of edge functionalized graphene nanostructures and bidimensional architectures in polymeric and metallic supports, with an outlook towards molecular sensing devices.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

Natural resources often stretch across borders that separate modern nation states. This can create conflict and limit opportunities for regulated consumption of their goods and services, but also provide opportunities for joint multinational efforts that exceed single country capabilities.

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

Promotor: W.T. de Groot

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Migratie is van alle tijden. Toen de Verenigde Staten werd ‘herontdekt’, trokken veel mensen daar naartoe. Ook Nederland koloniseerde een deel van Amerika en gaf het de naam Nieuw-Nederland. Masterstudent Geschiedenis Pepijn Doornenbal doet onderzoek in de VS naar hoe er in Nieuw-Nederland werd omgegaan…

Drie Nederlandse onderzoeksinstituten – waaronder het Leidse KITLV – gaan vervolgonderzoek doen naar het geweldsgebruik tijdens de dekolonisatieoorlog in Nederlands-Indië (1945 – 1950). Het kabinet stelt daarvoor 4,1 miljoen euro beschikbaar.