Promotor: K.E. Schalm, Co-promotor: S.S. Lee

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

Het centrale doel is de systematische bestudering van verschillen in criminaliteitspatronen en sociale controle tussen migranten en niet-migranten in het vroegmoderne Frankfurt am Main.

By training with virtual opponents known as computer generated forces (CGFs), trainee fighter pilots can build the experience necessary for air combat operations, at a fraction of the cost of training with real aircraft.

A New Technology-Based Firm (NTBF) is a significant enabler of job creation and a driver of the economy through stimulating innovation.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

In astronomy, the interpration of observations and measurements plays a crucial role: we rely purely and fundamentally on the information that reaches us as observers. And 80% of all matter in the universe is undetectable directly.

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

Heart failure is a major health care problem with high mortality.

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Hydrogen fuel cells are expected to be pivotal in the energetic transition towards renewable energy sources such as solar and wind power. However, their industrial scalability is severely hindered by the high cost and degradation rate of platinum catalysts, one of their key components. Addressing this…

Op 22 maart 2024 sprak Branda Katan haar oratie uit, getiteld ‘Duurzaamheid via aansprakelijkheid? Verwacht er niet te veel van’. Zij hield de oratie ter gelegenheid van haar aanstelling als bijzonder hoogleraar ondernemingsrecht aan de Universiteit Leiden, een leerstoel ingesteld door de Vereniging…

In this thesis, we study different curved single crystals because of the diversity of surface structures across their curvature.

This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids.

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

Een wetenschappelijk onderzoek naar de versterking van de verantwoordelijkheid van gecontroleerde entiteiten zelf rondom de accountantscontrole en de jaarverslaggeving.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Cardiovascular diseases are a leading cause of death worldwide, and better models are urgently needed for disease progression studies and drug development.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

Dit gedeelte bevat een overzicht van onze alumni, het loopbaanperspectief naast het doctoraat en "Alumni in beeld", waar we enkele voorbeelden geven van de carrières van sommige van onze alumni na hun promotie.

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

Lezing

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

Promotor: Prof.dr. C.W.J. Beenakker

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

Wij richten ons op natuurlijke producten van onderzoek, de traditionele geneeskunde, etnobotanie en fytochemie.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

De programmagroep Onderwijswetenschappen verzorgt onderwijs op het gebied van onderwijs, het leren en de ontwikkeling van leerlingen in de schoolcontext. Studenten worden aangemoedigd uitkomsten van wetenschappelijk onderzoek te gebruiken om hun mening over het onderwijsbeleid en de onderwijspraktijk…

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

The investigation into the bidirectional communication between the gut and its host is a rapidly growing area of research, attracting considerable attention for its potential to provide crucial insights into health and disease.

De onderzoeksgroep Governance of Crises bestudeert fenomenen, dynamieken en actoren die te maken hebben met crisisgovernance. Het Crisis Research Center (CRC) van de Universiteit Leiden maakt deel uit van deze onderzoeksgroep.

Op 17 november 2021 verdedigde Cyril-Igor Grigorieff het proefschrift 'The Regime for International Air Carrier Liability'. Het promotieonderzoek is begeleid door prof.dr. P. Mendes de Leon en prof.dr. V. Correia (University Paris Saclay).

Humanity stands at a pivotal juncture, facing the dual challenge of environmental sustainability and rapid population growth, projected to exceed 11 billion by century’s end.

Promotor: B. van de Water

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

Promotor: Prof.dr. B.R. Katzy

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers