In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

Promotor: Prof.dr. J.N. Kok

This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

The Sun and all the stars in the night sky reside in the Milky Way galaxy. In the at-rest reference frame of the Galaxy, typical stars travel with velocities of about 100-200 kilometres per second.

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

Promotores: Prof.dr. M. Franx, Prof.dr. M. Kriek (Univ. of California at Berkeley)

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

In this work the reconstruction of a tau neutrino signal in the KM3NeT detector is discussed.

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

In the era of big data, extracting insights from complex datasets is a key challenge. This thesis demonstrates the superiority of graph-based methods over traditional clustering (e.g., k-means, DBSCAN) and outlier detection for analyzing high-dimensional and noisy data.

The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

In this thesis, we address two problems concerning the tautological rings of the moduli space of curves.

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

The AI Collaboration Centre focuses on delivering Smart Computing for Science & Industry. This is reflected in our long-term collaborations with industry and government partners. These partnerships keep our research grounded in real-world applicability while opening new directions within computer sc…

This dissertation focuses on investigating the public communication around quantum science and technology that may affect public engagement.

The main theme of this thesis is the theoretical study of Gaussian processes as a tool in Bayesian nonparametric statistics.

Discover the Summer School Program Population Health Management by LUMC and learn about strategies to deal with current issues and developments in healthcare.

Search and conversational systems have become central to how people access information and perform tasks.

In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality⁠.

De Oorlogsgravenstichting publiceert dit jaar ter gelegenheid van het 75-jarig bestaan wekelijks een portret van een oorlogsslachtoffer. Op 24 januari werd de tekening van Irawan Soejono, Leids student en Indonesisch verzetsstrijder, onthuld op de Leidse begraafplaats Groenesteeg, de plek waar Soejono…

Op vijf mei vieren wij de vrijheid, een groot goed dat niet vanzelfsprekend is. Wij vroegen studenten en medewerkers wat vrijheid voor hun betekent.

‘Het Leidse horzelnest moet uitgebrand worden,’ zei de NSB-er Robert van Genechten in november 1942, doelend op de Universiteit Leiden. Vanwaar deze haat jegens Leiden? Universiteitshistoricus Willem Otterspeer schreef een boek over onze universiteit in oorlogstijd, gebaseerd op bijzonder, persoonlijk…

Bij het Beleg van Leiden, in 1574, stierf een derde van de bevolking. Nog jaarlijks herdenkt de stad het einde van deze belegering met hutspot, haring en wittebrood. En Leiden staat niet alleen: steden zijn al duizenden jaren het toneel van strijd.

Hoe ontwikkelde het Nederlandse vluchtelingenbeleid zich in een periode waarin opeenvolgende coalitiekabinetten verantwoordelijk waren voor dit beleid tijdens vluchtelingencrises tussen 1913 en 2017, en welke overwegingen kunnen deze ontwikkeling verklaren?

Wetlands provide many ecosystem goods and services which include fish production. The sustainability of small-scale fisheries (SSF) has received considerable attention in recent years because fish is one of the major sources of animal protein to a considerable fraction of the global population which…

Hoe beïnvloeden heftige oorlogservaringen verschillende generaties? Studenten maakten een video over aangrijpende familieverhalen. Ze interviewden medestudenten en schrijfster Dubravka Ugrešić. De première was op 4 mei tijdens 'Uur van Herinnering'. Bekijk deze online herdenking.

Een groep vertrouwelingen waaronder een oud-student van Meijers voorkwam zijn deportatie naar een vernietigingskamp. Cleveringahoogleraar Marjan Schwegman openbaarde in haar oratie op 27 november de vervolgingsgeschiedenis van de Joodse hoogleraar Eduard Meijers.

What are the pressing issues of our time, and how can different disciplines come together to address them? Studium Generale and Leiden University College (LUC) present the Global Challenges series: events that bring together researchers from LUC and experts from other disciplines to tackle a shared…

How were the Russians, under early modern conditions, able to incorporate this distant, undeveloped and, because frequent nomadic attacks, dangerous territory? And what role did the Kolyvan-Voskresensk plants play in this process?

Prof.dr. P. Stevenhagen, Prof.dr. K. Belabas (Universite Bordeaux I)

How and to what extent the historic house (re-)constructs identity through image-making in China.

eLaw onderzoekt de rol van het recht in de informatiemaatschappij: hoe kan het recht bijdragen aan een goede werking van informatie- en communicatietechnologie, en het gebruik ervan door burgers, bedrijven en overheden?

Webinar with Q&A

Kunst en vrije tijd, Kunst en vrije tijd

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

Polycyclic aromatic hydrocarbons (PAHs) are the most abundant class of organic compounds in space. The PAH field evolves from the constant interaction between experimentalists, theorists, modellers and observers. While laboratory research and quantum chemical calculations together set up the molecular…

Promotor: C. W. J. Beenakker, Yu. V. Nazarov, Co-promotor: J. Tworzydlo

This book explores the spiritual potential of faith, mysticism and transcendence in answer to the dangers of a mythologised state and the sacro-sanctification of (liberal) democracy and its rule of law.

Promotor: Prof.dr. A.G.G.M. Tielens

Promotor: R.D. Gill, F. Taroni

Carbonaceous asteroids preserve a record of early solar system processes, where minerals and organic molecules, like polycyclic aromatic hydrocarbons (PAHs), offer clues to planetary evolution and prebiotic chemistry.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

Promotores: J.C. van Houwelingen, S.A. van de Geer