How can we develop and further improve life cycle impact assessment methods, characterisation factors and normalisation factors?

In this thesis we study bistable reaction-diffusion equations on lattice domains.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Promotor: Prof.dr. S.F. Portegies Zwart

This dissertation combines the use of defined microenvironments, high-resolution fluorescence microscopy, and time-resolved analysis, to study intracellular and cellular motility.

Producing green energy has become the main goal in our society in the search of reducing or eliminating the carbon emission from fossil fuels.

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

In this thesis we investigate cosmology and the large scale structure of the Universe using cosmological simulations.

Promotores: J. Jonkers, K.E. de Visser

Promotores: P. Stevenhagen, A. Enge Co-Promotor: T.C. Streng

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Bicarbonate buffer is largely found in nature due to its ability to regulate pH variations around neutral values. As the pH changes, so does the speciation of the buffer.

De Cleveringaleerstoel is ingesteld door de Universiteit Leiden ter herinnering aan hoogleraar Rudolph Pabus Cleveringa en zijn moedige optreden in november 1940 tijdens de Duitse bezetting en ter herdenking van de bevrijding in 1945.

De Hans Franken is een eerbetoon aan prof. dr. mr. Hans Franken, één van de oprichters van eLaw in 1985.

De afdeling eLaw van de Universiteit Leiden is toonaangevend in Europa in onderzoek naar het snijvlak tussen recht en digitale technologieën.

Promotores: Prof.dr. G.A. Persoon & Prof. dr. H.H. de Iongh

With the advent of multicore processors and data centers, computer hardware has become increasingly parallel, allowing one to run multiple pieces of software at the same time on different machines. Coordination of these pieces is best expressed in a coordination language as an explicit interaction protocol…

We consider the propagation of electrical signals through nerve fibres.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.

Promotor: A.P. IJzerman

Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Control of infectious diseases poses continuous challenges for human health.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System⁠. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune⁠.

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

Promotor: A.P. IJzerman

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Multi-objective evolutionary computation aims to find high quality (Pareto optimal) solutions that represent the trade-off between multiple objectives.

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

Consequences for sediment stability and seston trapping

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

Promotor: Prof.dr. S. Haring

Indicators to measure progress in de-linking economic growth and environmental pressure.

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

Materials balances have been used in the recent past for the analysis of substance oriented environmental problems and the formulation of measures for environmental policy. In this study an integrated tool, based on the materials balance principle, has been developed for the analysis of both environmental…

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

Promotores: H.A. Udo De Haes, P.M. Brakefield

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius