Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

Promotor: K.J. Batenburg, Co-promotor: A.W. van der Vaart, B. de Smit

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Promotor: H.V.J. Linnartz

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

This thesis involves three topics: benchmarking discrete optimization algorithms, empirical analyses of evolutionary computation, and automatic algorithm configuration.

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

Promotor: Prof.dr. E Gittenberger, Co-Promotores: C.H.J.M. Fransen, B.W. Hoeksema

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Promotores: G.W. Canters, T.J. Aartsma

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

Recentelijk is een Special Issue van de European Journal of Criminology verschenen, die is samengesteld door Marieke Liem, Universitair Docent Criminologie bij het Instituut voor Strafrecht & Criminologie, en William Pridemore.

Promotor: C.J. ten Cate

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

This dissertation, Layered Loyalties: The Natuurkundige Commissie in the Netherlands Indies (1820-1850), studies the Natuurkundige Commissie.

This thesis studies the geometry of representation varieties and character stacks. These are spaces parametrizing the representations of a finitely generated group, typically the fundamental group of a compact manifold, into an algebraic group G.

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.

This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.

This thesis investigates reactive interfaces in surface science across three domains: heterogeneous catalysis, environmental nanoplastics, and two-dimensional materials.

Alumni-activiteit

The combination of data science and sports is a hot topic. In a talk during the opening of the Academic Year at the Faculty of Science, Professor Joost Kok explained what data analytics can teach us about sports.

Martin Richardson, die in 1997 afstudeerde aan het toenmalige Leiden LLM Programme in European Community Law (nu: Leiden Adv LLM European and International Business Law, EIBL), is onlangs benoemd tot Senator van het College of Justice in Schotland. Dat betekent dat hij nu rechter is van de hoogste civiele…

In haar proefschrift ‘How politics becomes news and news becomes politics’ geeft Luzia Helfer meer inzicht in beweegredenen van journalisten en politici om politiek nieuws ‘op te pakken’. Promotie op vrijdag 9 december.

Op 3 mei jongstleden werd de 10e Niko Tinbergenlezing georganiseerd. De lezingen werden dit jaar verzorgd door Steven Pinker en Rivke Jaffe. De beelden van de lezing van Steven Pinker zijn nu online terug te kijken en daarnaast is er een fotoreportage gemaakt.

Migratie is van alle tijden. Toen de Verenigde Staten werd ‘herontdekt’, trokken veel mensen daar naartoe. Ook Nederland koloniseerde een deel van Amerika en gaf het de naam Nieuw-Nederland. Masterstudent Geschiedenis Pepijn Doornenbal doet onderzoek in de VS naar hoe er in Nieuw-Nederland werd omgegaan…

Het was lastig om ambtenaren van de eerste Trump-administratie zover te krijgen te spreken over hun ervaringen op werk, maar het lukte socioloog Jaime Lee Kucinskas. Het beeld dat daaruit is ontstaan, is volgens haar niet al te best. ‘Hoe meer ik met ze sprak, hoe meer emoties ik zag. Ze waren ontzettend…