In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

Studievoorlichting

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

The aromatic infrared bands (AIBs) seen throughout the interstellar medium (ISM) are generally thought to be carried by polycyclic aromatic hydrocarbons (PAHs) and their nitrogen analogues (PANHs).

The thesis is about how auxin and AGC kinases regulate male fertility. The main AGC kinases studied in this thesis is PDK1, PDK2 and AGC1.5, AGC1.7.

This thesis investigates reactive interfaces in surface science across three domains: heterogeneous catalysis, environmental nanoplastics, and two-dimensional materials.

Na de master kiezen de meeste alumni voor een baan in het bedrijfsleven of bij de overheid.

Kom naar Leiden, praat bij met oud-studiegenoten, ontmoet andere vakgenoten en krijg een inkijkje in de huidige stand van zaken van onderwijs en onderzoek van je oude opleiding!

What is the optimal design of sandy solutions for sustainable climate change adaption, from an ecological, biophysical and societal point of view?

Menselijke cellen beschermen hun eiwitten tegen ontvouwen en samenklonteren. Dat ontdekten biofysicus Alireza Mashaghi en zijn team na zeven jaar diepgaand onderzoek naar de vouwmechanismen van eiwitten. Met een nieuwe, baanbrekende methode slaagde het team erin om een afzonderlijk eiwit te vouwen en…

If mankind wants to survive into the 22nd century, we will need to change the way we live drastically. The human impact on our planet is everywhere, we are changing the atmosphere, the oceans and the land, leading to global warming, climate change, loss of biodiversity and pervasive pollution. There…

This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…

Dit proefschrift beschrijft een collectie aan alternatieve strategieën voor het begrijpen, ontwerpen en toepassen van lipide nanosystemen, waarin de rol van de bio-nano interacties centraal staan. In het bijzonder wordt gekeken naar de interactie van RNA-lipide nanosystemen, bekend van de toepassing…

hotocatalysis has emerged as a powerful tool for enabling challenging transformations in organic synthesis. This thesis explores the development of several photocatalytic reactions designed to form carbon-heteroatom bonds from less-functionalized precursors.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

Promotores: W.J.G.M. Peijnenburg, G.R. de Snoo, Co-promotor: M.G. Vijver

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.

The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…

Inaugurale rede

The main goal of this thesis is to achieve advanced control of binding properties in bis-pyrrolic and macrocyclic pyrrolic receptors by light.

Promotor: Prof.dr. G.A. van der Marel, Co-Promotor: J.D.C. Codée

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Soil biodiversity is of great importance for the maintenance of multifunctionality in terrestrial ecosystems.

Promotor: G.R. de Snoo, Co-promotores: M.G. Vijver, J.P.M. Vink

Overkleeft

Biodiversity enables ecosystems to thrive through the synergy of functional differences among organisms. While human well-being strongly depends on biodiversity-driven ecosystem services, human actions are also at the root of current unprecedented biodiversity declines.

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Anthropogenic change is reshaping ecological systems, raising concerns about increasing transmission of infectious diseases. Among these, mosquito-borne diseases may be particularly sensitive to environmental change, as their transmission depends on vector populations.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

This thesis combines field and laboratory studies to address some of the most pressing questions in the field of microplastic research.

Leiden University offers a unique range of summer courses where you can broaden or deepen your knowledge or share your expertise with fellow students. The choice of academic courses is very diverse, ranging from Law, Big Data, Languages and Linguistics to Maths and Natural Sciences, Biology, Biomedical…

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

Celebrating 20 years of environmental research in Cagayan Valley and Sierra Madre

Promotor: G.R. de Snoo Co-promotor: C.J.M. Musters

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

‘We moeten op zoek naar producten die gewone wegwerpplastics kunnen vervangen, bijvoorbeeld van plantmateriaal. Binnen een jaar of 20 is het gemiddelde plasticgebruik van een huishouden met grote slagen verminderd.’ Volgens Thijs Bosker, Universitair Hoofddocent aan het Leiden University College, in…

Promotie

Oncode Accelerator wil de manier waarop we kankerbehandelingen ontwikkelen innoveren: binnen het programma wordt de patiënt centraal gesteld.