The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.

Promotor: Prof.dr. M. Ubbink

Promotores: Prof.dr. G. Miley & Prof.dr. J.M. van den Broek

Promotor: E.F. Smets Co-promotor: J. Geml

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Promotor: H.V.J. Linnartz

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Promotor: Prof.dr. J. Kuiper

Surface plasmons (SPs) are surface waves at the interface between a dielectric and a good metal, and are formed by the interaction between light and the free electrons at the metal-dielectric interface. They provide strong field confinement for optical fields, opening new possibilities for enhanced…

Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

A key step in the synthesis of oligosaccharides and glycoconjugates is the formation of the glycosidic bond.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

Promotor: J. A. Bouwstra

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Lezing

Welke rol spelen stress en angst bij de vorming van nocebo hyperalgesie?

Lipid nanoparticles (LNPs) have enabled the success of mRNA vaccines but remain limited in broader therapeutic use by challenges in delivery efficiency, targeting, and mechanistic understanding.

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

Onderzoek naar de onderliggende principes van de menselijke taal.

In this thesis the links between allergy and intestinal health, the gut microbiome (GM), and external factors were studied by exploring the metabolome in longitudinal clinical studies and in vitro models.

Conventional food supplies procured from rural areas are increasingly vulnerable to disruptions caused by extreme weather, geopolitical instability, and logistical bottlenecks.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

De collegereeks ‘Het Nederlandse crisismanagement stelsel: leren van de praktijk’ gaat vrijdag 22 april van start. Vijf vragen aan Peter Bos en Jeroen Wolbers over deze colleges én de betekenis van de samenwerking tussen de Universiteit Leiden en het NIPV (Nederlands Instituut Publieke Veiligheid).

Universitair docent Anna Dlabacova krijgt een Starting Grant van de European Research Council. Ze gaat de beurs van ongeveer 1,5 miljoen euro gebruiken om onderzoek te doen naar het Nederlandstalige getijden- en gebedenboek.

Leiden heeft er twee nieuwe minoren bij. Een over de functie van herinneringcultuur en een over de Islam. Ze gaan beide van start in september 2015. Waarom was het tijd om deze minoren te lanceren? Waarom zijn ze van belang en voor welke studenten zijn ze interessant? We vroegen initiatiefnemers Yra…

Gevaarlijke en klimaatvervuilende gaslekken sneller, goedkoper en betrouwbaarder opsporen: dat is wat de industrie nodig heeft. Universiteit Leiden en BigCircle Ventures gaan in een spin-off bedrijf met deze uitdaging aan de slag.

Op vrijdag 2 februari ging de Pre-University Class Midden-Oostenstudies van start. Dit extracurriculaire honoursonderwijs is bedoeld voor gemotiveerde en getalenteerde middelbare VWO-scholieren die zichzelf verder willen ontwikkelen naast hun reguliere studieprogramma en die meer kennis op willen doen…

Na zeven maanden hard werken was het zover: de deelnemers aan het Research Traineeship Programme sloten vrijdag 2 september hun onderzoek af met een pitch en een posterpresentatie.

Nieuwe stoffen identificeren om antibioticaresistente bacteriën te bestrijden. Onderzoekers van Leiden Universiteit en VU Amsterdam bundelen hun krachten om dit waar te maken, met een project gefinancierd door NWO’s Open Technologieprogramma (OTP). De samenwerking heeft bijna een miljoen euro toegekend…

Wetenschappers en niet-wetenschappers die samen baanbrekende citizen science-projecten bedenken over het meten, begrijpen en verminderen van luchtvervuiling. Dat gebeurde tijdens de eerste internationale workshop van het nieuw opgerichte Citizen Science Lab, van 22 tot en met 26 januari in het Lorentz…

Lotte van Dillen heeft een NWO-subsidie ontvangen voor onderzoek samen met Wilhelm Hofmann van de Universiteit Keulen en Henk van Steenbergen van de Universiteit Leiden. De psychologen stellen dat mensen meer genot na gaan streven wanneer ze minder aandacht aan consumptie besteden. Ze noemen dit verschijnsel …

Op 15 november origaniseerde de Brussels Privacy Hub en het Future of Privacy Forum in Brussel de 6e editie van het 'Brussels Privacy Symposium'. Het thema van dit jaar was 'Kwetsbare mensen, marginalisering en gegevensbescherming'.

Leidse wetenschappers gaan een bijdrage leveren aan de ontwikkeling van een camera voor de in aanbouw zijnde European Extremely Large Telescope. Op 28 september tekende de Nederlandse Onderzoekschool voor Astronomie een samenwerkingsovereenkomst met de European Southern Observatory.