The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

We investigate how radiation pressure can be used to influence the mechanical motion of a micro-mirror suspended from springs.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

Ontdek de cursus Communicating in Legal English van de Leiden Law Academy en verbeter uw juridisch Engelse vaardigheden. Lees hier meer!

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

In today's volatile market environments, companies must be able to continuously innovate. In this context, innovation does not only refer to the development of new products or business models but often also affects the entire organization, which has to transform its structures, processes, and ways of…

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

In this work the reconstruction of a tau neutrino signal in the KM3NeT detector is discussed.

Promotor: Prof.dr.ir. J.G.E.M. Fraaije, Co-promotor: A. Kros

How were the Russians, under early modern conditions, able to incorporate this distant, undeveloped and, because frequent nomadic attacks, dangerous territory? And what role did the Kolyvan-Voskresensk plants play in this process?

Promotor: Prof.dr. M.K. Richardson

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

Promotor: Prof.dr. C.W.J. Beenakker

Promotores: G.W. Canters, T.J. Aartsma

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

Promotores: Wim Jiskoot; Ferry Ossendorp

HEPGAME is a research project that combines the world’s fastest computer algebra system for High Energy Physics equations, FORM, with insights from artificial intelligence. The name combines High Energy Physics and Games.

It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.

International trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental improvements, while the opposite may be occurring.

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

This thesis describes the design, characterization and application of dextran based crosslinked network.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

During my PhD research, I studied the photon statistics of light emitted by a microcavity that contains a single quantum dot (QD) on resonance.

Promotor: Prof.dr. J.N. Kok

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

In this thesis, we developed new ways to use a technique called electroextraction (EE) to extract charged molecules from one liquid into another using an electric field.

This thesis develops a method for direction dependent calibration of the ionosphere in radio interferometric data.

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.