In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Promotores: J. Jonkers, K.E. de Visser

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

To an algebraic curve C over the complex numbers one can associate a non-negative integer g, the genus, as a measure of its complexity.

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

In this thesis we investigate cosmology and the large scale structure of the Universe using cosmological simulations.

Women Writing Mexico (WWM) is a network of women and men concerned with the human rights crisis in Mexico and more specifically, with the impact of structural forms of poverty, everyday violence, and discrimination based on gender, race, social class, and ethnicity, that particularly have an impact…

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.

Promotor: Prof.dr. T. Schmidt

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

Promotores: K.J. Batenburg, B. Koren

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

The aromatic infrared bands (AIBs) seen throughout the interstellar medium (ISM) are generally thought to be carried by polycyclic aromatic hydrocarbons (PAHs) and their nitrogen analogues (PANHs).

Promotor: Prof.dr. M. de Jong

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

More than 5,000 exoplanets have been found over the past couple of decades. These exoplanets show a tremendous diversity, ranging from scorching hot Jupiters, common super-Earths, to widely separated super-Jupiters on the planet/brown dwarf boundary.

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

Promotor: R. Cramer

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Promotor: Prof.dr. M. Danhof

Promotor: Prof.dr. G.P. van Wezel

In light of climate change, it is crucial to determine whether plant species can adapt to future climates to avoid extinction. Plants adapt to various conditions by altering their functional traits, such as leaf size or photosynthetic rate. Some traits appear linked and vary together between species,…

Promotores: H.A. Udo De Haes, P.M. Brakefield

For optimization problems, it is often unclear how to choose the most appropriate optimization algorithm. As such, rigorous benchmarking practices are critical to ensure we can gain as much insight into the strengths and weaknesses of these types of algorithms.

Promotor: K.E. Schalm, Co-promotor: S.S. Lee

Promotor: A. Achúcarro, Co-promotor: A. Boyarsky

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

What is the current relevance of the ethics of counterterrorism and what is the added value of ethics support within the practice of counterterrorism?

In this thesis, I focused on studying the above- and belowground interactions of J. vulgaris from a plant-soil feedback (hereafter, PSF) perspective. I investigated the temporal variation of negative PSF and examined the effects of root-associated bacteria on plant performance and aboveground herbiv…

Promotor: G.R. de Snoo

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

Promotor: K.J. Batenburg